Disease relevance of mod(mdg4)

• Baculovirus IAPs and P35, an inhibitor of aspartate-specific cysteine proteases, blocked Doom-induced apoptosis [1].

High impact information on mod(mdg4)

• The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators [2].
• Homeotic transformations in E(var)3-93D mutants indicate an involvement of the gene products in regulation of homeotic gene complexes [2].
• Mutations in E(var)3-93D exhibit an imprinting-like effect on the Y chromosome [2].
• An antiserum raised against E(var)3-93D protein detects this chromosomal protein in a large subset of sites in polytene chromosomes [2].
• Like OpIAP and CpIAP, DIAP1 inhibited actinomycin D-induced apoptosis and apoptosis induced by Doom [3].

Biological context of mod(mdg4)

• Thus, IAPs might block apoptosis by interacting with and modifying the behavior of Doom-like proteins that reside in cellular apoptotic pathways [1].

Anatomical context of mod(mdg4)

• Ultrastructural characterization of synaptic boutons in bpd demonstrated abnormal layering of the postsynaptic specialization or subsynaptic reticulum (SSR) [4].
• Synaptic terminals in bpd mutants developed abnormally, forming multiple branch points, overgrowing to inappropriate neighboring muscles, and establishing aberrant folding of postsynaptic membranes [4].

Associations of mod(mdg4) with chemical compounds

• The baculoviral BIR and RING finger regions, when separated, were unable to block apoptosis induced by actinomycin D or Doom [3].

References