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Gene Review

NTSR1  -  neurotensin receptor 1 (high affinity)

Homo sapiens

Synonyms: High-affinity levocabastine-insensitive neurotensin receptor, NT-R-1, NTR, NTR1, NTRH, ...
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High impact information on NTSR1

  • The distributions of immunoreactive NTRH and 125I-NT binding sites along somatodendritic plasma membranes were highly correlated and homogeneous, suggesting that membrane-targeted NTRH proteins were functional and predominantly extrasynaptic [1].
  • In keeping with this hypothesis, an association has recently been reported between schizophrenia and the gene encoding the neurotensin high affinity receptor (NTSR1) [2].
  • The nucleotide sequence of the GHS-R is most closely related to the neurotensin receptor-1 (NT-R1) (35% overall protein identity) [3].

Biological context of NTSR1

  • Therefore, as a follow-up to our earlier work on neurotensin, we have now sought to test the hypothesis that DNA sequence variants that alter the structure or expression of the NTSR1 gene (VAPSEs) are associated with schizophrenia [2].

Anatomical context of NTSR1


Regulatory relationships of NTSR1


  1. Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra. Boudin, H., Pélaprat, D., Rostène, W., Pickel, V.M., Beaudet, A. J. Neurosci. (1998) [Pubmed]
  2. The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia. Austin, J., Buckland, P., Cardno, A.G., Williams, N., Spurlock, G., Hoogendoorn, B., Zammit, S., Jones, G., Sanders, R., Jones, L., McCarthy, G., Jones, S., Bray, N.J., McGuffin, P., Owen, M.J., O'Donovan, M.C. Mol. Psychiatry (2000) [Pubmed]
  3. Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors. McKee, K.K., Tan, C.P., Palyha, O.C., Liu, J., Feighner, S.D., Hreniuk, D.L., Smith, R.G., Howard, A.D., Van der Ploeg, L.H. Genomics (1997) [Pubmed]
  4. The effect of neurotensin on insulin-induced proliferation of human fibroblasts. Scarpa, R.C., Carraway, R.E., Cochrane, D.E. Peptides (2004) [Pubmed]
  5. Neurotensin induces mating in Saccharomyces cerevisiae cells that express human neurotensin receptor type 1 in place of the endogenous pheromone receptor. Leplatois, P., Josse, A., Guillemot, M., Febvre, M., Vita, N., Ferrara, P., Loison, G. Eur. J. Biochem. (2001) [Pubmed]
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