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Gene Review

Ntsr1  -  neurotensin receptor 1

Mus musculus

Synonyms: NT-1R, NT-R-1, NTR-1, NTR1, Neurotensin receptor type 1, ...
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Disease relevance of Ntsr1


Psychiatry related information on Ntsr1

  • In order to investigate whether "endogenous" NT may act as a natural occurring antipsychotic or may mediate antipsychotic drug activity, the effects of the selective NT receptor antagonists SR 48692 and SR 142948A were analyzed in different behavioural tests of locomotor activity using vehicle, amphetamine, or haloperidol in mice [6].

High impact information on Ntsr1


Chemical compound and disease context of Ntsr1

  • This indicates that despite the results with the recently-cloned levocabastine-sensitive NT receptors (NTR) in the rat (NTR-2) and mouse (NTRL), levocabastine by itself does not mediate either hypothermia or antinociception at NT receptors [8].

Biological context of Ntsr1

  • The NT-1R(-/-) mice were hyperthermic; their body temperature was not affected by intracerebroventricular (i.c.v.) administration of NT, contrasting with the hypothermia induced in NT-1R(+/+) mice [2].
  • These results provide evidence that Ntr-1 gene regulation involves both positive and negative regulatory elements located in the 5'-flanking region and that Ntr-1 gene activation involves the coordinate activation or induction of several factors, including a CACCC box binding complex [3].
  • One of the QTL (chromosome 2, 80 cM) for NTR(H) density and hypnotic sensitivity is linked to the NTR(H) gene, Ntsr [9].
  • Simple sequence length polymorphisms were used to identify quantitative trait loci (QTL) influencing hypnotic and hypothermic sensitivity to ethanol, NTR(H) and low-affinity neurotensin receptor densities and NT-ir levels in LSXSS recombinant inbred strains [9].
  • The gene deletion also resulted in the loss of NTR1 expression as determined by reverse transcription-polymerase chain reaction and in situ hybridization [10].

Anatomical context of Ntsr1


Associations of Ntsr1 with chemical compounds


Physical interactions of Ntsr1


Regulatory relationships of Ntsr1


Other interactions of Ntsr1


Analytical, diagnostic and therapeutic context of Ntsr1


  1. Evidence for additional neurotensin receptor subtypes: neurotensin analogs that distinguish between neurotensin-mediated hypothermia and antinociception. Tyler, B.M., Cusack, B., Douglas, C.L., Souder, T., Richelson, E. Brain Res. (1998) [Pubmed]
  2. Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia. Remaury, A., Vita, N., Gendreau, S., Jung, M., Arnone, M., Poncelet, M., Culouscou, J.M., Le Fur, G., Soubrié, P., Caput, D., Shire, D., Kopf, M., Ferrara, P. Brain Res. (2002) [Pubmed]
  3. Sequences required for induction of neurotensin receptor gene expression during neuronal differentiation of N1E-115 neuroblastoma cells. Tavares, D., Tully, K., Dobner, P.R. J. Biol. Chem. (1999) [Pubmed]
  4. Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor. Gully, D., Canton, M., Boigegrain, R., Jeanjean, F., Molimard, J.C., Poncelet, M., Gueudet, C., Heaulme, M., Leyris, R., Brouard, A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  5. Expression of neurotensin and NT1 receptor in human breast cancer: a potential role in tumor progression. Souazé, F., Dupouy, S., Viardot-Foucault, V., Bruyneel, E., Attoub, S., Gespach, C., Gompel, A., Forgez, P. Cancer Res. (2006) [Pubmed]
  6. Blockade of neurotensin receptors affects differently hypo-locomotion and catalepsy induced by haloperidol in mice. Casti, P., Marchese, G., Casu, G., Ruiu, S., Pani, L. Neuropharmacology (2004) [Pubmed]
  7. Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain. Mazella, J., Botto, J.M., Guillemare, E., Coppola, T., Sarret, P., Vincent, J.P. J. Neurosci. (1996) [Pubmed]
  8. In vivo studies with low doses of levocabastine and diphenhydramine, but not pyrilamine, antagonize neurotensin-mediated antinociception. Tyler, B.M., Groshan, K., Cusack, B., Richelson, E. Brain Res. (1998) [Pubmed]
  9. Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: hypnotic and hypothermic effects. Erwin, V.G., Markel, P.D., Johnson, T.E., Gehle, V.M., Jones, B.C. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  10. The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin. Pettibone, D.J., Hess, J.F., Hey, P.J., Jacobson, M.A., Leviten, M., Lis, E.V., Mallorga, P.J., Pascarella, D.M., Snyder, M.A., Williams, J.B., Zeng, Z. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  11. Comparison of mice deficient in the high- or low-affinity neurotensin receptors, Ntsr1 or Ntsr2, reveals a novel function for Ntsr2 in thermal nociception. Maeno, H., Yamada, K., Santo-Yamada, Y., Aoki, K., Sun, Y.J., Sato, E., Fukushima, T., Ogura, H., Araki, T., Kamichi, S., Kimura, I., Yamano, M., Maeno-Hikichi, Y., Watase, K., Aoki, S., Kiyama, H., Wada, E., Wada, K. Brain Res. (2004) [Pubmed]
  12. Specific involvement of neurotensin type 1 receptor in the neurotensin-mediated in vivo dopamine efflux using knock-out mice. Leonetti, M., Brun, P., Clerget, M., Steinberg, R., Soubrié, P., Renaud, B., Suaud-Chagny, M.F. J. Neurochem. (2004) [Pubmed]
  13. Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue. Martin, S., Vincent, J.P., Mazella, J. J. Cell. Sci. (2002) [Pubmed]
  14. Radiolabeled ligands specific for the G protein-coupled state of neurotensin receptors. Gaudriault, G., Zsürger, N., Vincent, J.P. J. Neurochem. (1996) [Pubmed]
  15. Identification and expression of a variant isoform of the levocabastine-sensitive neurotensin receptor in the mouse central nervous system. Botto, J.M., Sarret, P., Vincent, J.P., Mazella, J. FEBS Lett. (1997) [Pubmed]
  16. Regional and cellular distribution of low affinity neurotensin receptor mRNA in adult and developing mouse brain. Sarret, P., Beaudet, A., Vincent, J.P., Mazella, J. J. Comp. Neurol. (1998) [Pubmed]
  17. Amphetamine-elicited striatal Fos expression is attenuated in neurotensin null mutant mice. Fadel, J., Dobner, P.R., Deutch, A.Y. Neurosci. Lett. (2006) [Pubmed]
  18. Desensitization of neurotensin receptor-mediated cyclic GMP formation in neuroblastoma clone N1E-115. Gilbert, J.A., Strobel, T.R., Richelson, E. Biochem. Pharmacol. (1988) [Pubmed]
  19. Novel bioactive and stable neurotensin peptide analogues capable of delivering radiopharmaceuticals and molecular beacons to tumors. Achilefu, S., Srinivasan, A., Schmidt, M.A., Jimenez, H.N., Bugaj, J.E., Erion, J.L. J. Med. Chem. (2003) [Pubmed]
  20. Changes in neurotensin receptor binding in mice after chronic ethanol consumption. Campbell, A.D., Erwin, V.G. Ann. N. Y. Acad. Sci. (1992) [Pubmed]
  21. Neurotensin and its analogs--correlation of specific binding with stimulation of cyclic GMP formation in neuroblastoma clone N1E-115. Gilbert, J.A., Moses, C.J., Pfenning, M.A., Richelson, E. Biochem. Pharmacol. (1986) [Pubmed]
  22. Role of signal transduction systems in neurotensin receptor down-regulation induced by agonist in murine neuroblastoma clone N1E-115 cells. Yamada, M., Yamada, M., Richelson, E. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  23. Regulation of DARPP-32 Thr75 phosphorylation by neurotensin in neostriatal neurons: involvement of glutamate signalling. Matsuyama, S., Fukui, R., Higashi, H., Nishi, A. Eur. J. Neurosci. (2003) [Pubmed]
  24. Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development. Hermans-Borgmeyer, I., Hermey, G., Nykjaer, A., Schaller, C. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  25. Identification of the receptor subtype involved in the analgesic effect of neurotensin. Dubuc, I., Sarret, P., Labbé-Jullié, C., Botto, J.M., Honoré, E., Bourdel, E., Martinez, J., Costentin, J., Vincent, J.P., Kitabgi, P., Mazella, J. J. Neurosci. (1999) [Pubmed]
  26. Purification of the neurotensin receptor from mouse brain by affinity chromatography. Mazella, J., Chabry, J., Zsurger, N., Vincent, J.P. J. Biol. Chem. (1989) [Pubmed]
  27. Neurotensin and a non-peptide neurotensin receptor antagonist control human colon cancer cell growth in cell culture and in cells xenografted into nude mice. Maoret, J.J., Anini, Y., Rouyer-Fessard, C., Gully, D., Laburthe, M. Int. J. Cancer (1999) [Pubmed]
  28. Indirect inhibitory effect of a neurotensin receptor antagonist on human colon cancer (LoVo) growth. Iwase, K., Evers, B.M., Hellmich, M.R., Kim, H.J., Higashide, S., Gully, D., Townsend, C.M. Surgical oncology. (1996) [Pubmed]
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