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Gene Review:

Circp1 - circadian photosensitivity 1

Mus musculus

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Disease relevance of Circp1

In these mice with heterogeneous genetic backgrounds as well, mice with retinal degeneration were always less sensitive to light, suggesting that reduced circadian photosensitivity is caused by retinal degeneration [1].

Psychiatry related information on Circp1

In our previous study, retinally degenerate CBA/J (rd/rd) mice were found to have lower circadian photosensitivity for phase-shifting the locomotor activity rhythms than normal CBA/N(+/+) mice [2].

High impact information on Circp1

Surprisingly, rod loss in Rpe65 knockout mice resulted in restoration of circadian photosensitivity [3].
(2) Could the reported age-related decline in circadian photosensitivity of rodents be linked to changes in the population of melanopsin RGCs [4]?
As a result, several putative QTLs onthree separate chromosomes (8, 12, 17) were detected, which indicates that circadian photosensitivity in rd mice is altered by multiple genes [5].
Mapping quantitative trait loci affecting circadian photosensitivity in retinally degenerate mice [5].
Mice bearing specific inherited lesions of both rod and cone photoreceptors retain circadian photosensitivity as assessed by photoentrainment of behavioural rhythms and the light-induced suppression of pineal melatonin [6].

Anatomical context of Circp1

Nevertheless, the possibility that circadian photosensitivity is the responsibility of multiple photoreceptor classes including both rod/cone and novel photopigments remains [6].

References

Differences in circadian photosensitivity between retinally degenerate CBA/J mice (rd/rd) and normal CBA/N mice (+/+). Yoshimura, T., Nishio, M., Goto, M., Ebihara, S. J. Biol. Rhythms (1994) [Pubmed]
Spectral sensitivity of photoreceptors mediating phase-shifts of circadian rhythms in retinally degenerate CBA/J (rd/rd) and normal CBA/N (+/+)mice. Yoshimura, T., Ebihara, S. J. Comp. Physiol. A (1996) [Pubmed]
Nonvisual light responses in the Rpe65 knockout mouse: rod loss restores sensitivity to the melanopsin system. Doyle, S.E., Castrucci, A.M., McCall, M., Provencio, I., Menaker, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Light-induced c-fos in melanopsin retinal ganglion cells of young and aged rodless/coneless (rd/rd cl) mice. Semo, M., Lupi, D., Peirson, S.N., Butler, J.N., Foster, R.G. Eur. J. Neurosci. (2003) [Pubmed]
Mapping quantitative trait loci affecting circadian photosensitivity in retinally degenerate mice. Yoshimura, T., Yokota, Y., Ishikawa, A., Yasuo, S., Hayashi, N., Suzuki, T., Okabayashi, N., Namikawa, T., Ebihara, S. J. Biol. Rhythms (2002) [Pubmed]
Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice. Lucas, R.J., Freedman, M.S., Lupi, D., Munoz, M., David-Gray, Z.K., Foster, R.G. Behav. Brain Res. (2001) [Pubmed]

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