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Gene Review:

TNFRSF4 - tumor necrosis factor receptor superfamily...

Felis catus

Synonyms: CD134, OX40

de Parseval, A. et al., Joshi, A. et al., de Parseval, A. et al., Shimojima, M. et al.

de Parseval, Grant, Sastry, Elder,

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Disease relevance of TNFRSF4

Use of CD134 as a primary receptor by the feline immunodeficiency virus [1].

Psychiatry related information on TNFRSF4

Although increased permissiveness to FIV infection of CD4+ CD25- cells following mitogenic stimulation correlated strongly with upregulation of surface CXCR4, it did not correlate with CD134 expression [2].

High impact information on TNFRSF4

Binding of the FIV major surface glycoprotein on activated CD4+ T cells was observed through direct interaction with CD134 whereas, on activated CD8+ T cells, the binding was CD134-independent and mediated by CXCR4 and, to a lesser extent, heparan sulfate proteoglycans [3].
Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor [3].
In addition, the number of CD4+ CD25+ cells that expressed the primary receptor CD134 was greater than for CD4+ CD25- cells [2].
CD134 expression promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation [1].

Anatomical context of TNFRSF4

CD8+ T cells remained negative for CD134 expression regardless of the activation state [3].

Regulatory relationships of TNFRSF4

Recombinant soluble CD134 (sCD134) facilitated feline immunodeficiency virus (FIV) entry into CXCR4-positive, cell surface CD134-negative target cells. sCD134-activated entry was dose dependent and CXCR4 dependent [4].

References

Use of CD134 as a primary receptor by the feline immunodeficiency virus. Shimojima, M., Miyazawa, T., Ikeda, Y., McMonagle, E.L., Haining, H., Akashi, H., Takeuchi, Y., Hosie, M.J., Willett, B.J. Science (2004) [Pubmed]
Preferential feline immunodeficiency virus (FIV) infection of CD4+ CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors. Joshi, A., Garg, H., Tompkins, M.B., Tompkins, W.A. J. Virol. (2005) [Pubmed]
Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor. de Parseval, A., Chatterji, U., Sun, P., Elder, J.H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Sequential CD134-CXCR4 interactions in feline immunodeficiency virus (FIV): soluble CD134 activates FIV Env for CXCR4-dependent entry and reveals a cryptic neutralization epitope. de Parseval, A., Grant, C.K., Sastry, K.J., Elder, J.H. J. Virol. (2006) [Pubmed]

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