Gene Review:
CXCR4 - chemokine (C-X-C motif) receptor 4
Felis catus
- Preferential feline immunodeficiency virus (FIV) infection of CD4+ CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors. Joshi, A., Garg, H., Tompkins, M.B., Tompkins, W.A. J. Virol. (2005)
- The second extracellular loop of CXCR4 determines its function as a receptor for feline immunodeficiency virus. Willett, B.J., Adema, K., Heveker, N., Brelot, A., Picard, L., Alizon, M., Turner, J.D., Hoxie, J.A., Peiper, S., Neil, J.C., Hosie, M.J. J. Virol. (1998)
- Expression of mRNA of chemokine receptor CXCR4 in feline mammary adenocarcinoma. Tanabe, S., Nakadai, T., Furuoka, H., Oomachi, T., Kobayashi, Y., Omata, Y., Koyama, T., Hondo, E., Uzuka, Y., Sarashina, T., Ducusin, R.J., Shida, T., Dorf, M.E. Vet. Rec. (2002)
- CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes. Nakagaki, K., Nakagaki, K., Takahashi, K., Schols, D., De Clercq, E., Tabira, T. J. Neurovirol. (2001)
- Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor. de Parseval, A., Chatterji, U., Sun, P., Elder, J.H. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Factors that increase the effective concentration of CXCR4 dictate feline immunodeficiency virus tropism and kinetics of replication. de Parseval, A., Ngo, S., Sun, P., Elder, J.H. J. Virol. (2004)
- Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus. Willett, B.J., Cannon, C.A., Hosie, M.J. J. Virol. (2002)
- Feline lentiviruses demonstrate differences in receptor repertoire and envelope structural elements. Smirnova, N., Troyer, J.L., Schissler, J., Terwee, J., Poss, M., VandeWoude, S. Virology (2005)
- Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses. Willett, B.J., Picard, L., Hosie, M.J., Turner, J.D., Adema, K., Clapham, P.R. J. Virol. (1997)
- Sequential CD134-CXCR4 interactions in feline immunodeficiency virus (FIV): soluble CD134 activates FIV Env for CXCR4-dependent entry and reveals a cryptic neutralization epitope. de Parseval, A., Grant, C.K., Sastry, K.J., Elder, J.H. J. Virol. (2006)
- Feline peripheral blood mononuclear cells express message for both CXC and CC type chemokine receptors. Kovacs, E.M., Baxter, G.D., Robinson, W.F. Arch. Virol. (1999)
- Placental immunopathology and pregnancy failure in the FIV-infected cat. Weaver, C.C., Burgess, S.C., Nelson, P.D., Wilkinson, M., Ryan, P.L., Nail, C.A., Kelly-Quagliana, K.A., May, M.L., Reeves, R.K., Boyle, C.R., Coats, K.S. Placenta (2005)