Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

CES1 - carboxylesterase 1

Felis catus

Miyazaki, M. et al., Miyazaki, M. et al., Miyazaki, M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CES1

Domestic cats exhibit physiological proteinuria due to the excretion of cauxin, a carboxylesterase, into the urine [1].

High impact information on CES1

Here, we report that cauxin, a carboxylesterase excreted as a major urinary component, regulates felinine production [2].
The deduced amino acid sequence shared 47% identity with the rat liver carboxylesterase (EC 3.1.1.1), and both the serine hydrolase active site and the carboxylesterase-specific sequence were conserved [3].

Analytical, diagnostic and therapeutic context of CES1

Molecular cloning and characterization of a novel carboxylesterase-like protein that is physiologically present at high concentrations in the urine of domestic cats (Felis catus) [3].

References

Species-, sex-, and age-dependent urinary excretion of cauxin, a mammalian carboxylesterase. Miyazaki, M., Yamashita, T., Hosokawa, M., Taira, H., Suzuki, A. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2006) [Pubmed]
A major urinary protein of the domestic cat regulates the production of felinine, a putative pheromone precursor. Miyazaki, M., Yamashita, T., Suzuki, Y., Saito, Y., Soeta, S., Taira, H., Suzuki, A. Chem. Biol. (2006) [Pubmed]
Molecular cloning and characterization of a novel carboxylesterase-like protein that is physiologically present at high concentrations in the urine of domestic cats (Felis catus). Miyazaki, M., Kamiie, K., Soeta, S., Taira, H., Yamashita, T. Biochem. J. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg