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Chemical Compound Review:

Felinine (2S)-2-amino-3-(4-hydroxy-2- methyl-butan-2...

Synonyms: l-Felinine, AG-F-60641, CHEBI:39390, KB-78140, CTK4I9732, ...

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High impact information on Felinine

In vitro enzyme assays indicated that cauxin hydrolyzed the felinine precursor 3-methylbutanol-cysteinylglycine to felinine and glycine [1].
The reaction of urea and felinine was independent of pH over the range of 3-10 [2].
Castration of half the male cats induced a parallel fall in both testosterone and felinine that was reversed following testosterone supplementation [3].
Importance of sulfate, cysteine and methionine as precursors to felinine synthesis by domestic cats (Felis catus) [4].

Associations of Felinine with other chemical compounds

The data obtained in the present study support the concept that felinine, which has been found in Felidae species only, may be testosterone dependent [5].

Analytical, diagnostic and therapeutic context of Felinine

A rapid capillary electrophoresis method was established to quantify felinine (2-amino-7-hydroxy-5,5-dimethyl-4-thiaheptanoic acid) in cat urine and used to investigate felinine stability [6].

References

A major urinary protein of the domestic cat regulates the production of felinine, a putative pheromone precursor. Miyazaki, M., Yamashita, T., Suzuki, Y., Saito, Y., Soeta, S., Taira, H., Suzuki, A. Chem. Biol. (2006) [Pubmed]
Felinine stability in the presence of selected urine compounds. Rutherfurd, S.M., Kitson, T.M., Woolhouse, A.D., McGrath, M.C., Hendriks, W.H. Amino Acids (2007) [Pubmed]
Relationship between plasma testosterone and urinary felinine in the growing kitten. Tarttelin, M.F., Hendriks, W.H., Moughan, P.J. Physiol. Behav. (1998) [Pubmed]
Importance of sulfate, cysteine and methionine as precursors to felinine synthesis by domestic cats (Felis catus). Hendriks, W.H., Rutherfurd, S.M., Rutherfurd, K.J. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2001) [Pubmed]
Twenty-four hour felinine [corrected] excretion patterns in entire and castrated cats. Hendriks, W.H., Tarttelin, M.F., Moughan, P.J. Physiol. Behav. (1995) [Pubmed]
Use of capillary (zone) electrophoresis for determining felinine and it's application to investigate the stability of felinine. Rutherfurd, S.M., Zhang, F., Harding, D.R., Woolhouse, A.D., Hendriks, W.H. Amino Acids (2004) [Pubmed]

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