Disease relevance of Cats

• This is the first description of a dystrophin-deficient muscular dystrophy in domestic cats [1].
• PLV establishes productive infection in domestic cats following parenteral exposure but, in contrast to domestic cat FIV, it does not cause T-cell dysregulation [2].
• The three clades, which occurred not only together in the same population but throughout Africa, were as divergent from each other as were homologous pol sequences of lentivirus isolated from distinct feline species, i.e., puma and domestic cat [3].
• The common form of spontaneous diabetes mellitus that occurs in domestic cats bears close resemblance clinically and pathologically to human type 2 diabetes mellitus (T2DM) [4].
• Digoxigenin labelled whole chromosomal DNA probes directed against three feline members of the genus Porphyromonas (P. gingivalis VPB 3492, P. circumdentaria NCTC 12469T and P. salivosa VPB 3313) were used to identify and quantify organisms in samples taken from the gingival margins of 40 domestic cats with different grades of periodontal disease [5].
• Cat (e1) is a major allergen in patients with asthma from Siberia, Russia [6].

High impact information on Cats

• Primary plague pneumonia contracted from a domestic cat at South Lake Tahoe, Calif [7].
• Members of a domestic cat colony with chylomicronemia share many phenotypic features with human lipoprotein lipase (LPL) deficiency [8].
• Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein sequence analysis and cDNA cloning [9].
• Domestic cats and dogs with lymphoblastic disease were treated with prednisone, 2 mg/kg/day, for 14 days, and the outcome of therapy was correlated with DEAE chromatograms of glucocorticoid binders, using 3H-triamcinolone as ligand [10].
• Felinine is a unique sulfur-containing amino acid found in the urine of domestic cats and select members of the Felidae family [11].

Chemical compound and disease context of Cats

• Because of the known association between feline central retinal degeneration (CRD) and taurine deficiency in domestic cats, plasma concentrations of taurine were measured in this tiger [12].
• Effects of weight gain and loss on metabolic rate, glucose tolerance, and serum lipids in domestic cats [13].
• The domestic cat as a host for Brugian filariasis in South Kalimantan (Borneo), Indonesia [14].
• The pharmacokinetics and toxicity profile of stampidine (STAMP, DDE-113, HI-113, N-[p-(4-bromophenyl)-2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester, CAS 217178-62-6) were studied in beagle dogs and feline immunodeficiency virus-infected domestic cats [15].
• Thirty-one (31) formalin-fixed hearts from domestic cats who died of idiopathic cardiomyopathy were randomly selected from pathology archives [16].

Biological context of Cats

• Characterization of MHC cDNA clones in the domestic cat. Diversity and evolution of class I genes [17].
• We have further evaluated the susceptibility of the domestic cat to diet-induced atherosclerosis, the ultimate intent being to discern the atherogenic risk due to lipoprotein lipase deficiency in an affected feline kindred with a phenotype very similar to that of the human form of this condition [18].
• Luteal function in the domestic cat during pseudopregnancy and after treatment with prostaglandin F2 alpha [19].
• The 9747-bp provirus of this virus, FIV-Oma, has typical lentivirus organization with LTRs, gag, pol, and env open reading frames (ORFs), putative vif and rev ORFs, and an ORF similar to ORF2/ORFA of domestic cat FIV isolates [20].
• Molecular phylogeny of mitochondrial cytochrome b and 12S rRNA sequences in the Felidae: ocelot and domestic cat lineages [21].

Anatomical context of Cats

• Definition of the human T-cell epitopes of Fel d 1, the major allergen of the domestic cat [22].
• We have investigated thyroid hormone deiodination in the liver, kidney and thyroid of the domestic cat [23].
• Tritiated proline was administered to domestic cats during the development of their permanent dentition [24].
• Three experiments were conducted to study the uptake of oral beta-carotene by blood plasma and leukocytes in domestic cats [25].
• Relative effects of pentobarbital and chloralose on the responsiveness of neurons in sensorimotor cerebral cortex of the domestic cat [26].

Associations of Cats with chemical compounds

• Limited variation in the domestic cat Feca-DRA gene was observed, but abundant variation in the Feca-DRB gene was seen comprising 61 distinct DRB alleles [27].
• Preliminary studies of vitamin B6 metabolism in three adult domestic cats detected very little pyridoxic acid in the urine [28].
• To develop the model, 8 healthy domestic cats were given a 50% pancreatectomy, which was followed by treatment with growth hormone and dexamethasone [29].
• Identification of pyridoxine 3-sulfate, pyridoxal 3-sulfate, and N-methylpyridoxine as major urinary metabolites of vitamin B6 in domestic cats [28].
• BACKGROUND: A heterodimeric acidic glycoprotein (Fel d 1) has been defined as the major allergen of the domestic cat [22].

Gene context of Cats

• Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene [30].
• TYRP1 was mapped on chromosome D4 within 5 cM of a highly polymorphic microsatellite, previously found to be fixed in a cat breed selected for the chocolate (b) allele of the B locus, which reinforced TYRP1 as a candidate gene for the B locus in the domestic cat [31].
• Chromosomal mapping of enzyme loci in the domestic cat: GSR to C2, ADA and ITPA to A3, and LDHA-ACP2 to D1 [32].
• Demonstration of biological activity of CD40 ligand (CD154) in the domestic cat [33].
• Tas1r2 in tiger and cheetah and in six healthy adult domestic cats all show the similar deletion and stop codons [34].

Analytical, diagnostic and therapeutic context of Cats

• The complete primary structure of Fel dI (International Union of Immunological Societies nomenclature), the major allergen produced by the domestic cat, Felis domesticus, was determined by protein sequence analysis and cDNA cloning [9].
• Analysis of HPLC fractions of extracted fecal samples from the radiolabel-injected domestic cats revealed that E2 immunoreactivity coincided primarily with the unconjugated metabolized [14C]E2 peak, whereas progestogen immunoreactivity coincided with a single conjugated epimer and multiple unconjugated pregnenolone epimers [35].
• The effects of gonadotropin treatment and laparoscopic artificial insemination (AI) on embryo quality, serum progesterone and estradiol concentrations, and luteal progesterone content were examined in the domestic cat [36].
• The renal excretion of iodine following oral administration of Gastrografin to domestic cats [37].
• Sequence analysis of MHC DRB alleles in domestic cats from the United Kingdom [38].

References