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Gene Review

hrg  -  hiiragi

Drosophila melanogaster

Synonyms: CG9854, Dmel\CG9854, PAP, Pap, l(2)07619, ...
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High impact information on hrg


Biological context of hrg

  • A mutation that reduced the enzymatic activity of Hrg failed to reverse the phenotype of hrg mutants, suggesting that the enzymatic activity of Hrg was required to rescue the wing phenotype [2].

Associations of hrg with chemical compounds

  • Poly(A) polymerase (PAP) has a role in two processes, polyadenylation of mRNA precursors in the nucleus and translational control of certain mRNAs by cytoplasmic elongation of their poly(A) tails, particularly during early development [1].


  1. Control of poly(A) polymerase level is essential to cytoplasmic polyadenylation and early development in Drosophila. Juge, F., Zaessinger, S., Temme, C., Wahle, E., Simonelig, M. EMBO J. (2002) [Pubmed]
  2. The hiiragi gene encodes a poly(A) polymerase, which controls the formation of the wing margin in Drosophila melanogaster. Murata, T., Nagaso, H., Kashiwabara , S., Baba, T., Okano, H., Yokoyama, K.K. Dev. Biol. (2001) [Pubmed]
  3. Positive and negative control of Serrate expression during early development of the Drosophila wing. Bachmann, A., Knust, E. Mech. Dev. (1998) [Pubmed]
  4. hiiragi, a gene essential for wing development in Drosophila melanogaster, affects the Notch cascade. Murata, T., Ogura, K., Murakami, R., Okano, H., Yokoyama, K.K. Genes Genet. Syst. (1996) [Pubmed]
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