High impact information on hrg

• This demonstrates that regulation of the PAP level is essential for controlled cytoplasmic polyadenylation and early development [1].
• A mutation in the hrg gene resulted in a decrease in the level of the hrg transcript and was associated with a notched wing phenotype [2].
• The levels of expression of wingless and cut at the presumptive wing margins were reduced in the late third-instar larvae of hrg mutants [2].
• Second, transcriptional downregulation during third larval instar is mediated by hiiragi [3].
• hiiragi, a gene essential for wing development in Drosophila melanogaster, affects the Notch cascade [4].

Biological context of hrg

• A mutation that reduced the enzymatic activity of Hrg failed to reverse the phenotype of hrg mutants, suggesting that the enzymatic activity of Hrg was required to rescue the wing phenotype [2].

Associations of hrg with chemical compounds

• Poly(A) polymerase (PAP) has a role in two processes, polyadenylation of mRNA precursors in the nucleus and translational control of certain mRNAs by cytoplasmic elongation of their poly(A) tails, particularly during early development [1].

References