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Gene Review

PAPOLG  -  poly(A) polymerase gamma

Homo sapiens

Synonyms: FLJ12972, Neo-PAP, Neo-poly(A) polymerase, PAP-gamma, PAP2, ...
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High impact information on PAPOLG

  • PAP-2 contains two clip domains at its amino terminus and a catalytic domain at its carboxyl terminus, whereas PAP-1 has only one clip domain [1].
  • This enzyme, designated prophenoloxidase-activating proteinase-2 (PAP-2), differs from another PAP, previously isolated from integuments of the same insect (PAP-1) [1].
  • PAP-2 mRNA was not detected in naive larval fat body or hemocytes, but it became abundant in these tissues after the insects were injected with bacteria [1].
  • A novel nuclear human poly(A) polymerase (PAP), PAP gamma [2].
  • Although PAP is present as a single-copy gene in the bell pepper genome, Southern blots using PAP2 as a probe revealed multiple homologous copies [3].

Biological context of PAPOLG


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