Gene Review:
Spn55B - Serpin 55B
Drosophila melanogaster
Synonyms:
CG10913, Dmel\CG10913, Sp6, Spn6, sp-6, ...
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Disease relevance of Spn6
- We produced serpin-6 in an Escherichia coli expression system and purified the soluble protein by nickel affinity and hydrophobic interaction chromatography [1].
High impact information on Spn6
- M. sexta serpin-6 is 55% similar in amino acid sequence to Drosophila melanogaster serpin-5, an immune-responsive protein [1].
- We recently isolated Manduca sexta serpin-6 from hemolymph of the bacteria-challenged larvae, which selectively inhibited proPO-activating proteinase-3 (PAP-3) (Wang, Y., and Jiang, H. (2004) Insect Biochem. Mol. Biol. 34, 387-395) [1].
- To further characterize its structure and function, we cloned serpin-6 from an induced fat body cDNA library using a PCR-derived probe [1].
- Manduca sexta serpin-6 regulates immune serine proteinases PAP-3 and HP8. cDNA cloning, protein expression, inhibition kinetics, and function elucidation [1].
Anatomical context of Spn6
- Serpin-6 is constitutively present in hemolymph of naive larvae, and its mRNA and protein levels significantly increase after a bacterial injection [1].
References
- Manduca sexta serpin-6 regulates immune serine proteinases PAP-3 and HP8. cDNA cloning, protein expression, inhibition kinetics, and function elucidation. Zou, Z., Jiang, H. J. Biol. Chem. (2005) [Pubmed]
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