Gene Review:
SERPINI1 - serpin peptidase inhibitor, clade I...
Homo sapiens
Synonyms:
Neuroserpin, PI-12, PI12, Peptidase inhibitor 12, Serpin I1, ...
- Association between conformational mutations in neuroserpin and onset and severity of dementia. Davis, R.L., Shrimpton, A.E., Carrell, R.W., Lomas, D.A., Gerhard, L., Baumann, B., Lawrence, D.A., Yepes, M., Kim, T.S., Ghetti, B., Piccardo, P., Takao, M., Lacbawan, F., Muenke, M., Sifers, R.N., Bradshaw, C.B., Kent, P.F., Collins, G.H., Larocca, D., Holohan, P.D. Lancet (2002)
- Adjuvant treatment with neuroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke. Zhang, Z., Zhang, L., Yepes, M., Jiang, Q., Li, Q., Arniego, P., Coleman, T.A., Lawrence, D.A., Chopp, M. Circulation (2002)
- Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26. Chang, W.S., Chang, N.T., Lin, S.C., Wu, C.W., Wu, F.Y. Genes Chromosomes Cancer (2000)
- Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous system. Yepes, M., Lawrence, D.A. Thromb. Haemost. (2004)
- Accumulation of mutant neuroserpin precedes development of clinical symptoms in familial encephalopathy with neuroserpin inclusion bodies. Galliciotti, G., Glatzel, M., Kinter, J., Kozlov, S.V., Cinelli, P., Rülicke, T., Sonderegger, P. Am. J. Pathol. (2007)
- Familial dementia caused by polymerization of mutant neuroserpin. Davis, R.L., Shrimpton, A.E., Holohan, P.D., Bradshaw, C., Feiglin, D., Collins, G.H., Sonderegger, P., Kinter, J., Becker, L.M., Lacbawan, F., Krasnewich, D., Muenke, M., Lawrence, D.A., Yerby, M.S., Shaw, C.M., Gooptu, B., Elliott, P.R., Finch, J.T., Carrell, R.W., Lomas, D.A. Nature (1999)
- Cell toxicity and conformational disease. Carrell, R.W. Trends Cell Biol. (2005)
- Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis. Sharp, L.K., Mallya, M., Kinghorn, K.J., Wang, Z., Crowther, D.C., Huntington, J.A., Belorgey, D., Lomas, D.A. FEBS J. (2006)
- Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival. Hastings, G.A., Coleman, T.A., Haudenschild, C.C., Stefansson, S., Smith, E.P., Barthlow, R., Cherry, S., Sandkvist, M., Lawrence, D.A. J. Biol. Chem. (1997)
- Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum. Miranda, E., Römisch, K., Lomas, D.A. J. Biol. Chem. (2004)
- Human neuroserpin (PI12): cDNA cloning and chromosomal localization to 3q26. Schrimpf, S.P., Bleiker, A.J., Brecevic, L., Kozlov, S.V., Berger, P., Osterwalder, T., Krueger, S.R., Schinzel, A., Sonderegger, P. Genomics (1997)
- Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells. Parmar, P.K., Coates, L.C., Pearson, J.F., Hill, R.M., Birch, N.P. J. Neurochem. (2002)
- Biochemical characterization of a neuroserpin variant associated with hereditary dementia. Yazaki, M., Liepnieks, J.J., Murrell, J.R., Takao, M., Guenther, B., Piccardo, P., Farlow, M.R., Ghetti, B., Benson, M.D. Am. J. Pathol. (2001)
- Induction of neuroserpin expression in rat frontal cortex after chronic antidepressant treatment and electroconvulsive treatment. Tanaka, S., Yamada, M., Kitahara, S., Higuchi, T., Honda, K., Kamijima, K., Yamada, M. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. (2006)
- Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro. Barker-Carlson, K., Lawrence, D.A., Schwartz, B.S. J. Biol. Chem. (2002)
- Gene expression of metabolic enzymes and a protease inhibitor in the prefrontal cortex are decreased in schizophrenia. Vawter, M.P., Shannon Weickert, C., Ferran, E., Matsumoto, M., Overman, K., Hyde, T.M., Weinberger, D.R., Bunney, W.E., Kleinman, J.E. Neurochem. Res. (2004)
- Familial conformational diseases and dementias. Crowther, D.C. Hum. Mutat. (2002)
- Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies. Onda, M., Belorgey, D., Sharp, L.K., Lomas, D.A. J. Biol. Chem. (2005)
- Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB. Belorgey, D., Sharp, L.K., Crowther, D.C., Onda, M., Johansson, J., Lomas, D.A. Eur. J. Biochem. (2004)
- Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro. Belorgey, D., Crowther, D.C., Mahadeva, R., Lomas, D.A. J. Biol. Chem. (2002)
- Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system. Teesalu, T., Kulla, A., Simisker, A., Sirén, V., Lawrence, D.A., Asser, T., Vaheri, A. Thromb. Haemost. (2004)
- Neuroserpin (PI-12) is upregulated in high-grade prostate cancer and is associated with survival. Hasumi, H., Ishiguro, H., Nakamura, M., Sugiura, S., Osada, Y., Miyoshi, Y., Fujinami, K., Yao, M., Hamada, K., Yamada-Okabe, H., Kubota, Y., Uemura, H. Int. J. Cancer (2005)