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Gene Review

ORC5  -  origin recognition complex, subunit 5

Homo sapiens

Synonyms: ORC5L, ORC5P, ORC5T, Orc5p, Origin recognition complex subunit 5, ...
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Disease relevance of ORC5L


High impact information on ORC5L

  • Mutations in the Walker A motif of Orc1p, Orc4p, or Orc5p reduced the binding efficiency of HsORC1-5 modestly (2- to 5-fold) [3].
  • Orc2, Orc3, and Orc5 also are detected in non-proliferating cells like cardiac myocytes, adrenal cortical cells, and neurons, suggesting an additional role of these proteins in non-proliferating cells [4].
  • Two alleles of ORC5L were identified, one with and one without an evolutionarily conserved purine nucleotide binding motif [1].
  • Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22 [2].
  • Polymerase chain reaction amplification and sequencing analysis of the coding region of the remaining ORC5L allele has not revealed any mutations in nine patients with AML or MDS exhibiting 7q22 deletions [2].

Biological context of ORC5L

  • We have identified a YAC clone that contains human ORC5L and maps to chromosome band 7q22 [5].
  • Xenopus laevis ORC-depleted extracts supplemented with HsORC1-5 supported prereplication complex formation and X. laevis sperm DNA replication, whereas the complex with a mutation in the Walker A motif of the Orc1, Orc4, or Orc5 subunit did not [3].
  • 1. We have identified the S. pombe ORC5 gene and located it in a cosmid mapped on chromosome II [5].

Anatomical context of ORC5L


  1. ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases. Quintana, D.G., Thome, K.C., Hou, Z.H., Ligon, A.H., Morton, C.C., Dutta, A. J. Biol. Chem. (1998) [Pubmed]
  2. Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22. Fröhling, S., Nakabayashi, K., Scherer, S.W., Döhner, H., Döhner, K. Hum. Genet. (2001) [Pubmed]
  3. Studies of the properties of human origin recognition complex and its Walker A motif mutants. Giordano-Coltart, J., Ying, C.Y., Gautier, J., Hurwitz, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins. Thome, K.C., Dhar, S.K., Quintana, D.G., Delmolino, L., Shahsafaei, A., Dutta, A. J. Biol. Chem. (2000) [Pubmed]
  5. Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22. Ishiai, M., Dean, F.B., Okumura, K., Abe, M., Moon, K.Y., Amin, A.A., Kagotani, K., Taguchi, H., Murakami, Y., Hanaoka, F., O'Donnell, M., Hurwitz, J., Eki, T. Genomics (1997) [Pubmed]
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