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Gene Review

Nbl1  -  neuroblastoma 1, DAN family BMP antagonist

Rattus norvegicus

Synonyms: Dan, N03, Neuroblastoma suppressor of tumorigenicity 1, Zinc finger protein DAN
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Disease relevance of Nbl1

  • Differential screening-selected gene aberrative in neuroblastoma (DAN) gene (previously named N03 gene), whose expression is significantly reduced in transformed cells, has recently been demonstrated to have a tumor-suppressive activity in vitro [1].

High impact information on Nbl1

  • Nucleotide sequence analysis showed that the N03 protein is composed of 178 amino acid residues and does not have any sequence similarities with proteins in the data base [2].
  • Genomic Southern blot hybridization revealed that the N03 gene exists as a single copy in the rat genome and that closely related, single-copy genes are also present in chicken and human [2].
  • Two clones, which overexpressed N03 mRNA, showed a flatter phenotype, a reduced rate of growth, and a decreased ability to grow in soft agar [3].
  • Tumor-suppressive activity of N03 gene product in v-src-transformed rat 3Y1 fibroblasts [3].
  • Among those, one clone termed N03 showed nearly complete down-regulation in v-src-, v-mos and SV40-transformed 3Y1 cells [4].

Biological context of Nbl1

  • Introduction of N03 cDNA into SR-3Y1 cells using an expression vector resulted in suppression of transformed phenotypes such as high growth rate, colony-forming ability in soft agar and tumorigenicity in nude mice [4].

Analytical, diagnostic and therapeutic context of Nbl1

  • N03 mRNA was detected by Northern blot analysis in several tissues, including lung, kidney, intestine, and brain, but not in liver [2].
  • Culture media were analyzed for accumulation of stable oxidation products of NO (NO2- + N03-, designated as NOX-), cellular RNA was extracted for determination of iNOS mRNA levels by Northern blot analysis, and nuclear extracts were prepared for determination of NF-kappa B by electrophoretic mobility-shift assay [5].


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