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Gene Review:

IBD4 - inflammatory bowel disease 4

Homo sapiens

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Disease relevance of IBD4

Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis [1].
Linkage studies have identified a Crohn's disease susceptibility locus on chromosome 14 (14q11-12; IBD4) [2].

High impact information on IBD4

Our finding of significant linkage to D14S261 and the finding of suggestive linkage to the same locus in an independent study (multipoint LOD = 2.8) satisfies criteria for confirmed linkage, so we propose that the region of interest on chromosome 14q11-12 should be designated the IBD4 locus [3].
CONCLUSION: Genome scanning in a Flemish IBD population found nominal evidence for linkage on 1p, 4q, 10p12, and 14q11, overlapping with other genome scan results, with linkage on 14q11-12 supporting the IBD4 locus [1].
The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction [4].
PATIENTS AND METHODS: A total of 733 IBD families, comprising 892 affected sibling pairs, were genotyped for microsatellites D14S261, D14S283, D14S972, and D14S275, spanning the IBD4 locus [4].
METHODS: Standard histology, immunohistochemistry (monoclonal antibodies VL8 and VL2 and polyclonal antibody IE63 directed against VZV; monoclonal antibodies IBD4 and HH2 and polyclonal antibodies directed against HSVI and HSVII) and in situ hybridisation (anti-HSV and anti-VZV probes) were applied to formalin fixed, paraffin wax sections [5].

References

Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis. Vermeire, S., Rutgeerts, P., Van Steen, K., Joossens, S., Claessens, G., Pierik, M., Peeters, M., Vlietinck, R. Gut (2004) [Pubmed]
The interleukin-25 gene located in the inflammatory bowel disease (IBD) 4 region: no association with inflammatory bowel disease. Büning, C., Genschel, J., Weltrich, R., Lochs, H., Schmidt, H. Eur. J. Immunogenet. (2003) [Pubmed]
High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12. Duerr, R.H., Barmada, M.M., Zhang, L., Pfützer, R., Weeks, D.E. Am. J. Hum. Genet. (2000) [Pubmed]
The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction. Pierik, M., Yang, H., Barmada, M.M., Cavanaugh, J.A., Annese, V., Brant, S.R., Cho, J.H., Duerr, R.H., Hugot, J.P., McGovern, D.P., Paavola-Sakki, P., Radford-Smith, G.L., Pavli, P., Silverberg, M.S., Schreiber, S., Taylor, K.D., Vlietinck, R. Inflamm. Bowel Dis. (2005) [Pubmed]
Distribution of varicella zoster virus and herpes simplex virus in disseminated fatal infections. Nikkels, A.F., Delvenne, P., Sadzot-Delvaux, C., Debrus, S., Piette, J., Rentier, B., Lipcsei, G., Quatresooz, P., Piérard, G.E. J. Clin. Pathol. (1996) [Pubmed]

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