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Gene Review:

Preb - prolactin regulatory element binding

Mus musculus

Synonyms: C85705, Mammalian guanine nucleotide exchange factor mSec12, Prolactin regulatory element-binding protein, Sec12

Edgar, A.J., Weissman, J.T. et al., Taylor Clelland, C.L. et al.

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High impact information on Preb

The mammalian guanine nucleotide exchange factor mSec12 is essential for activation of the Sar1 GTPase directing endoplasmic reticulum export [1].
Preb is detectable in early stage embryos in the peripheral nervous system, developing liver, and surface ectoderm [2].
The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12 [3].
The Sec12 protein promotes efficient guanine nucleotide exchange on the Sar1 GTPase in the ER [3].
No inverse correlation between the respective levels of ABHD1 and Sec12 RNA was found to indicate that any RNA interference occurred [3].

References

The mammalian guanine nucleotide exchange factor mSec12 is essential for activation of the Sar1 GTPase directing endoplasmic reticulum export. Weissman, J.T., Plutner, H., Balch, W.E. Traffic (2001) [Pubmed]
Mapping and developmental expression analysis of the WD-repeat gene Preb. Taylor Clelland, C.L., Craciun, L., Bancroft, C., Lufkin, T. Genomics (2000) [Pubmed]
The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12. Edgar, A.J. BMC Genomics (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP009942	Anopheles gambiae str. PEST
PREB	Bos taurus
sec-12	Caenorhabditis elegans
PREB	Canis lupus familiaris
preb	Danio rerio
CG9175	Drosophila melanogaster
PREB	Gallus gallus
PREB	Homo sapiens
PREB	Macaca mulatta
PREB	Pan troglodytes
Preb	Rattus norvegicus
preb	Xenopus (Silurana) tropicalis

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