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Gene Review

PREB  -  prolactin regulatory element binding

Homo sapiens

Synonyms: Mammalian guanine nucleotide exchange factor mSec12, Prolactin regulatory element-binding protein, SEC12
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Disease relevance of PREB


Psychiatry related information on PREB

  • We propose that PREB has a role during human development and that abnormal dosage of this transcription factor may be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p [2].

High impact information on PREB

  • We suggest that Sec12p participates actively in the growth of COPII vesicles by charging new Sar1p-GTP molecules that insert at the boundary between a bud and the surrounding endoplasmic reticulum membrane [3].
  • In order to recapitulate a more authentic, GTP-dependent budding event, we introduced the Sar1p nucleotide exchange catalyst, Sec12p, and evaluated the dynamics of coat assembly and disassembly by light scattering and tryptophan fluorescence measurements [3].
  • By contrast, specific inhibition of endoplasmic reticulum export via overexpression of Sec12p or coexpression of a GTP-restricted form of Sar1p inhibits the anterograde transport of either cargo molecule in a similar manner [4].
  • However, three different rodent non-pituitary cell lines yielded a common shifted band, corresponding to a DNA sequence-specific PRE-binding protein (PREB) [5].
  • That PREB and ssPREB are distinct proteins was confirmed by the inability of their DNA binding sites to cross-compete binding of the proteins [5].

Biological context of PREB


Anatomical context of PREB


Associations of PREB with chemical compounds


Regulatory relationships of PREB


Other interactions of PREB

  • In the INS-1 cells, co-expression of PREB and the insulin promoter induced activity of the latter [6].


  1. Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity. Fliss, M.S., Hinkle, P.M., Bancroft, C. Mol. Endocrinol. (1999) [Pubmed]
  2. Cloning and characterization of human PREB; a gene that maps to a genomic region associated with trisomy 2p syndrome. Taylor Clelland, C.L., Levy, B., McKie, J.M., Duncan, A.M., Hirschhorn, K., Bancroft, C. Mamm. Genome (2000) [Pubmed]
  3. GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes. Futai, E., Hamamoto, S., Orci, L., Schekman, R. EMBO J. (2004) [Pubmed]
  4. The GTPase ARF1p controls the sequence-specific vacuolar sorting route to the lytic vacuole. Pimpl, P., Hanton, S.L., Taylor, J.P., Pinto-daSilva, L.L., Denecke, J. Plant Cell (2003) [Pubmed]
  5. Identification of a growth hormone gene promoter repressor element and its cognate double- and single-stranded DNA-binding proteins. Pan, W.T., Liu, Q.R., Bancroft, C. J. Biol. Chem. (1990) [Pubmed]
  6. Prolactin regulatory element binding protein as a potential transcriptional factor for the insulin gene in response to glucose stimulation. Ohtsuka, S., Murao, K., Imachi, H., Cao, W.M., Yu, X., Li, J., Iwama, H., Wong, N.C., Bancroft, C., Ishida, T. Diabetologia (2006) [Pubmed]
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