Gene Review:
SAR1 - Arf family GTPase SAR1
Saccharomyces cerevisiae S288c
Synonyms:
GTP-binding protein SAR1, Secretion-associated RAS-related protein 1, Small COPII coat GTPase SAR1, YPL218W
- Reconstitution of GTP-binding Sar1 protein function in ER to Golgi transport. Oka, T., Nishikawa, S., Nakano, A. J. Cell Biol. (1991)
- Traffic-independent function of the Sar1p/COPII machinery in proteasomal sorting of the cystic fibrosis transmembrane conductance regulator. Fu, L., Sztul, E. J. Cell Biol. (2003)
- Small GTP-binding proteins. Takai, Y., Sasaki, T., Matozaki, T. Physiol. Rev. (2001)
- Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle. Lee, M.C., Orci, L., Hamamoto, S., Futai, E., Ravazzola, M., Schekman, R. Cell (2005)
- COPII-coated vesicle formation reconstituted with purified coat proteins and chemically defined liposomes. Matsuoka, K., Orci, L., Amherdt, M., Bednarek, S.Y., Hamamoto, S., Schekman, R., Yeung, T. Cell (1998)
- A novel GTP-binding protein, Sar1p, is involved in transport from the endoplasmic reticulum to the Golgi apparatus. Nakańo, A., Muramatsu, M. J. Cell Biol. (1989)
- Isolation of a tobacco cDNA encoding Sar1 GTPase and analysis of its dominant mutations in vesicular traffic using a yeast complementation system. Takeuchi, M., Tada, M., Saito, C., Yashiroda, H., Nakano, A. Plant Cell Physiol. (1998)
- Isolation of Pichia pastoris genes involved in ER-to-Golgi transport. Payne, W.E., Kaiser, C.A., Bevis, B.J., Soderholm, J., Fu, D., Sears, I.B., Glick, B.S. Yeast (2000)
- Identification of SEC12, SED4, truncated SEC16, and EKS1/HRD3 as multicopy suppressors of ts mutants of Sar1 GTPase. Saito, Y., Yamanushi, T., Oka, T., Nakano, A. J. Biochem. (1999)
- Fission yeast and a plant have functional homologues of the Sar1 and Sec12 proteins involved in ER to Golgi traffic in budding yeast. d'Enfert, C., Gensse, M., Gaillardin, C. EMBO J. (1992)
- Purification and characterization of SAR1p, a small GTP-binding protein required for transport vesicle formation from the endoplasmic reticulum. Barlowe, C., d'Enfert, C., Schekman, R. J. Biol. Chem. (1993)
- Molecular analysis of SAR1-related cDNAs from a mouse pituitary cell line. Shen, K.A., Hammond, C.M., Moore, H.P. FEBS Lett. (1993)
- Structure of the Sec23/24-Sar1 pre-budding complex of the COPII vesicle coat. Bi, X., Corpina, R.A., Goldberg, J. Nature (2002)
- Requirement for a GTPase-activating protein in vesicle budding from the endoplasmic reticulum. Yoshihisa, T., Barlowe, C., Schekman, R. Science (1993)
- Sec16p potentiates the action of COPII proteins to bud transport vesicles. Supek, F., Madden, D.T., Hamamoto, S., Orci, L., Schekman, R. J. Cell Biol. (2002)
- Endoplasmic reticulum export of glycosyltransferases depends on interaction of a cytoplasmic dibasic motif with Sar1. Giraudo, C.G., Maccioni, H.J. Mol. Biol. Cell (2003)
- Inhibition of GTP hydrolysis by Sar1p causes accumulation of vesicles that are a functional intermediate of the ER-to-Golgi transport in yeast. Oka, T., Nakano, A. J. Cell Biol. (1994)
- Sed4p functions as a positive regulator of Sar1p probably through inhibition of the GTPase activation by Sec23p. Saito-Nakano, Y., Nakano, A. Genes Cells (2000)
- Characterization of yeast sar1 temperature-sensitive mutants, which are defective in protein transport from the endoplasmic reticulum. Yamanushi, T., Hirata, A., Oka, T., Nakano, A. J. Biochem. (1996)
- Secretory bulk flow of soluble proteins is efficient and COPII dependent. Phillipson, B.A., Pimpl, P., daSilva, L.L., Crofts, A.J., Taylor, J.P., Movafeghi, A., Robinson, D.G., Denecke, J. Plant Cell (2001)
- The presence of a Sar1 gene family in Brassica campestris that suppresses a yeast vesicular transport mutation Sec12-1. Kim, W.Y., Cheong, N.E., Je, D.Y., Kim, M.G., Lim, C.O., Bahk, J.D., Cho, M.J., Lee, S.Y. Plant Mol. Biol. (1997)