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Gene Review

PCDHGC3  -  protocadherin gamma subfamily C, 3

Homo sapiens

Synonyms: PC-43, PC43, PCDH-GAMMA-C3, PCDH-gamma-C3, PCDH2, ...
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High impact information on PCDHGC3

  • In this study, we show that Pcdh gamma C3 and Pcdh gamma B4 are specifically cleaved within their ectodomains by the disintegrin and metalloprotease ADAM10 [1].
  • This activity was Ca(2+)-dependent and was inhibited by the addition of anti-Pcdh2 antibody, indicating that the chimeric Pcdh2, and probably the wild-type Pcdh2, has Ca(2+)-dependent cell aggregation activity [2].
  • On immunofluorescence microscopy, the somas of Purkinje cells were diffusely stained with anti-human Pcdh2 antibody [2].
  • The present results suggest that Pcdh2, and possibly other protocadherins as well as protocadherin-related proteins such as Drosophila fat, mediate Ca(2+)-dependent and specific homophilic cell-cell interaction in vivo and play an important role in cell adhesion, cell recognition, and/or some other basic cell processes [2].
  • Using cDNA of human protocadherin 2A (pc2A; originally known as protocadherin 2) as a probe, we cloned a new member of the protocadherin 2 subfamily from mouse brain cDNA libraries and named it protocadherin 2C (pc2C) [3].

Biological context of PCDHGC3

  • Mixed cell aggregation assay using L cells and different types of transfectants showed that the activity of Pcdh2 was homophilic and molecular type specific and that Pcdh2 was transfectants did not aggregate with other types of transfectants or with L cells [2].
  • One type corresponds to rat Pcdh2; the other two types are distinct from Pcdh2 but contain the same sequence in their cytoplasmic domains and part of the 3' flanking sequence [4].

Anatomical context of PCDHGC3


Analytical, diagnostic and therapeutic context of PCDHGC3

  • In immunoprecipitation, the chimeric Pcdh2 co-precipitated with a 105 kDa and a 95 kDa protein, whereas wild-type Pcdh2 co-precipitated with no major protein [2].


  1. Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion. Reiss, K., Maretzky, T., Haas, I.G., Schulte, M., Ludwig, A., Frank, M., Saftig, P. J. Biol. Chem. (2006) [Pubmed]
  2. Protocadherin Pcdh2 shows properties similar to, but distinct from, those of classical cadherins. Obata, S., Sago, H., Mori, N., Rochelle, J.M., Seldin, M.F., Davidson, M., St John, T., Taketani, S., Suzuki, S.T. J. Cell. Sci. (1995) [Pubmed]
  3. Protocadherin 2C: a new member of the protocadherin 2 subfamily expressed in a redundant manner with OL-protocadherin in the developing brain. Hirano, S., Ono, T., Yan, Q., Wang, X., Sonta, S., Suzuki, S.T. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  4. A common protocadherin tail: multiple protocadherins share the same sequence in their cytoplasmic domains and are expressed in different regions of brain. Obata, S., Sago, H., Mori, N., Davidson, M., St John, T., Suzuki, S.T. Cell Adhes. Commun. (1998) [Pubmed]
  5. Studies on protocadherin-2 expression in the human fetal central nervous system. Omi, H., Kitagawa, M. Congenital anomalies. (2004) [Pubmed]
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