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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Coil  -  coilin

Rattus norvegicus

 
 
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High impact information on Coil

  • Coilin is shown to be a phosphoprotein that is phosphorylated on at least two additional sites during mitosis [1].
  • We have analyzed the number of nucleoli and CBs and the structural and molecular organization of CBs and nuclear speckles in the three neuronal types by using immunofluorescence with antibodies that recognize nucleoli (fibrillarin), CBs (coilin), and nuclear speckles (snRNPs), confocal microscopy, and electron microscopy [2].
  • The NLB may represent a compartment in the mammalian oocyte, akin to the sphere organelle of the amphibian oocyte (also reported to contain spliceosomal components and a p80-coilin-related protein) [3].
  • The intensity of the staining was lower using the antibody against nuclear lamin B. Immunocytochemical detection of the protein coilin revealed punctuated stained areas, 2-6 per nucleus, that probably correspond to the coiled bodies [4].

References

  1. Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis--evidence that the coiled body is a kinetic nuclear structure. Carmo-Fonseca, M., Ferreira, J., Lamond, A.I. J. Cell Biol. (1993) [Pubmed]
  2. Neuronal body size correlates with the number of nucleoli and Cajal bodies, and with the organization of the splicing machinery in rat trigeminal ganglion neurons. Pena, E., Berciano, M.T., Fernandez, R., Ojeda, J.L., Lafarga, M. J. Comp. Neurol. (2001) [Pubmed]
  3. Immunoelectron microscope analyses of rat germinal vesicle-stage oocyte nucleolus-like bodies. Kopecný, V., Landa, V., Malatesta, M., Martin, T.E., Fakan, S. Reprod. Nutr. Dev. (1996) [Pubmed]
  4. Immunocytochemical detection of structural and regulatory proteins in rat adrenal nuclear matrix. Neves, D., Magalhães, M.M., Magalhães, M.C. Biotechnic & histochemistry : official publication of the Biological Stain Commission. (1999) [Pubmed]
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