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Gene Review

Fbl  -  fibrillarin

Rattus norvegicus

Synonyms: Histone-glutamine methyltransferase, Nucleolar protein 1, rRNA 2'-O-methyltransferase fibrillarin
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Disease relevance of Fbl


Psychiatry related information on Fbl


High impact information on Fbl


Chemical compound and disease context of Fbl


Biological context of Fbl

  • Nucleolar chromosomes such as chromosomes no [15].
  • These observations indicate that the nucleolus-derived particles containing ribosomal protein S1 are different from cytoplasmic ribosomes and, in the living cell, are selectively recollected after mitosis into the newly formed nuclei and translocated into a specific nucleolar subcompartment, i.e., the granular component [16].
  • Our data are consistent with a model in which C/D small nucleolar RNA might play a role in the regulation of RNA editing [17].
  • Nuclear microinjection of mutant MRP RNAs revealed that nucleolar localization requires a sequence element (nucleotides 23-62) previously implicated as a binding site for a nucleolar protein, the To antigen [18].
  • Drug-induced dispersal of transcribed rRNA genes and transcriptional products: immunolocalization and silver staining of different nucleolar components in rat cells treated with 5,6-dichloro-beta-D-ribofuranosylbenzimidazole [19].

Anatomical context of Fbl

  • Using coimmunoprecipitation experiments, we show that the nucleolar and coiled-body protein Nopp140 interacts with both classes of snoRNPs [20].
  • These results demonstrate that SRP RNA concentrates in an intranucleolar location other than the classical stations of ribosome biosynthesis, suggesting that there may be nucleolar regions that are specialized for other functions [21].
  • Using anti-(U3)RNP autoantibodies, we have isolated and characterized two additional small nucleolar RNAs from HeLa cells, which are less abundant than U3 RNA [22].
  • Specifically, there appeared to be a general relaxation in the condensation state of the nucleoli, changes in both the number and size of the granular ribonucleoprotein components, and finally a reorganization of the nucleolar fibrillar reticulum [23].
  • This protein is not detected in the residual nucleolar structures of cells inactive in rRNA synthesis such as amphibian and avian erythrocytes [16].

Associations of Fbl with chemical compounds

  • This nucleolar 34-kDa protein resembles several nucleoplasmic proteins that are associated with heterogeneous nuclear RNA with respect to isoelectric point, Mr, presence of NG,NG-dimethylarginine, and its high glycine content [24].
  • Moreover, we have identified a brain-specific small RNA, termed MBII-52, which was predicted to function as a nucleolar C/D RNA, thereby targeting an A-to-I editing site (C-site) within the 5-HT2C serotonin receptor pre-mRNA for 2'-O-methylation [17].
  • Supplementation of the methionine-free diet with cystine blocks the nucleolar enlargement and the enhancement of the polymerase activity that would otherwise take place, but the dispensable amino acid does not affect the responses to a deprivation of one of the other essential amino acids [25].
  • Nucleolar protein B23 translocation after doxorubicin treatment in murine tumor cells [26].
  • Dietary administration of these compounds significantly decreased the expression of cell proliferation biomarkers (5-bromodeoxyuridine-labeling index and silver-stained nucleolar organizer regions protein number) of the nonlesional tongue squamous epithelium (P < 0.05) [27].

Physical interactions of Fbl


Regulatory relationships of Fbl


Other interactions of Fbl


Analytical, diagnostic and therapeutic context of Fbl

  • In the present study we describe the nucleolar localization of a specific ribosomal protein (S1) by immunofluorescence and immunoelectron microscopy using a monoclonal antibody (RS1-105) [16].
  • These results indicate that red blood cell-mediated microinjection of antibodies can be used to study nucleolar and nuclear antigens [36].
  • Localization was specifically in the dense fibrillar component of the nucleolus, as revealed by immunocytochemistry with a monoclonal antibody against fibrillarin, a known dense fibrillar component protein, as well as by digital optical sectioning microscopy and 3-D stereo reconstruction [18].
  • Dual probe in situ hybridization experiments confirmed that a significant fraction of nucleolar SRP RNA was not spatially coincident with 28S ribosomal RNA [21].
  • Indirect immunofluorescence microscopy on fixed and permeabilized Buffalo rat liver (BRL) cells with anti-p140 antibodies exhibited a distinct punctate nucleolar staining [38].


  1. Dictyostelium small nuclear RNA D2 is homologous to rat nucleolar RNA U3 and is encoded by a dispersed multigene family. Wise, J.A., Weiner, A.M. Cell (1980) [Pubmed]
  2. Differences in nucleolar antigens of rat liver and Novikoff hepatoma ascites cells. Davis, F.M., Busch, R.K., Yeoman, L.C., Busch, H. Cancer Res. (1978) [Pubmed]
  3. Multiple sites of action of N-hydroxy-2-acetylaminofluorene rat hepatic nuclear transcription. Yu, F.L., Grunberger, D. Cancer Res. (1976) [Pubmed]
  4. Characterization of nucleolar antigens of normal rat liver, regenerating rat liver, and Novikoff ascites hepatoma cells following in vitro translation of polyadenylic acid-containing messenger RNA. Satoh, K., Busch, H. Cancer Res. (1983) [Pubmed]
  5. Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: comparison with the protective effect of beta-carotene. Tanaka, T., Makita, H., Ohnishi, M., Hirose, Y., Wang, A., Mori, H., Satoh, K., Hara, A., Ogawa, H. Cancer Res. (1994) [Pubmed]
  6. Water deprivation in lactating rats: changes in nucleolar dry mass of paraventricular and supraoptic neurones. Russell, J.A. Cell Tissue Res. (1980) [Pubmed]
  7. X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Heiss, N.S., Knight, S.W., Vulliamy, T.J., Klauck, S.M., Wiemann, S., Mason, P.J., Poustka, A., Dokal, I. Nat. Genet. (1998) [Pubmed]
  8. Nopp140 shuttles on tracks between nucleolus and cytoplasm. Meier, U.T., Blobel, G. Cell (1992) [Pubmed]
  9. A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells. Tsai, R.Y., McKay, R.D. Genes Dev. (2002) [Pubmed]
  10. Ultrastructural study of the effect of bleomycin A2 on the nucleolus and its possibly related cytoplasmic constituents in Novikoff hepatoma cells. Daskal, Y., Crooke, S.T., Smetana, K., Busch, H. Cancer Res. (1975) [Pubmed]
  11. Effect of methylazoxymethanol acetate on rat liver nuclear and nucleolar RNA synthesis. Yu, F.L., Hunter, G., Cass, M., Barrett, A., Yap, T.G., Nowicki, D., Novak, R. Cancer Res. (1983) [Pubmed]
  12. Nucleolar phosphoproteins of normal rat liver and Novikoff hepatoma ascites cells. Kang, Y.J., Olson, M.O., Jones, C., Busch, H. Cancer Res. (1975) [Pubmed]
  13. Nucleolar changes in liver before the onset of deoxyribonucleic acid replication. Bailey, R.P., Rudert, W.A., Short, J., Lieberman, I. J. Biol. Chem. (1975) [Pubmed]
  14. Selective inhibition of rat liver nuclear RNA polymerase II by actinomycin D in vivo. Yu, F.L. Carcinogenesis (1980) [Pubmed]
  15. Establishment and chromosome studies of in vitro lines of chemically induced rat erythroblastic leukemia cells. Maeda, S., Uenaka, H., Ueda, N., Shiraishi, N., Suglyama, T. J. Natl. Cancer Inst. (1980) [Pubmed]
  16. Localization of ribosomal protein S1 in the granular component of the interphase nucleolus and its distribution during mitosis. Hügle, B., Hazan, R., Scheer, U., Franke, W.W. J. Cell Biol. (1985) [Pubmed]
  17. ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs. Vitali, P., Basyuk, E., Le Meur, E., Bertrand, E., Muscatelli, F., Cavaillé, J., Huttenhofer, A. J. Cell Biol. (2005) [Pubmed]
  18. Dynamic localization of RNase MRP RNA in the nucleolus observed by fluorescent RNA cytochemistry in living cells. Jacobson, M.R., Cao, L.G., Wang, Y.L., Pederson, T. J. Cell Biol. (1995) [Pubmed]
  19. Drug-induced dispersal of transcribed rRNA genes and transcriptional products: immunolocalization and silver staining of different nucleolar components in rat cells treated with 5,6-dichloro-beta-D-ribofuranosylbenzimidazole. Scheer, U., Hügle, B., Hazan, R., Rose, K.M. J. Cell Biol. (1984) [Pubmed]
  20. Conserved composition of mammalian box H/ACA and box C/D small nucleolar ribonucleoprotein particles and their interaction with the common factor Nopp140. Yang, Y., Isaac, C., Wang, C., Dragon, F., Pogacic, V., Meier, U.T. Mol. Biol. Cell (2000) [Pubmed]
  21. Signal recognition particle RNA localization within the nucleolus differs from the classical sites of ribosome synthesis. Politz, J.C., Lewandowski, L.B., Pederson, T. J. Cell Biol. (2002) [Pubmed]
  22. U3, U8 and U13 comprise a new class of mammalian snRNPs localized in the cell nucleolus. Tyc, K., Steitz, J.A. EMBO J. (1989) [Pubmed]
  23. Morphological study of the mammalian stress response: characterization of changes in cytoplasmic organelles, cytoskeleton, and nucleoli, and appearance of intranuclear actin filaments in rat fibroblasts after heat-shock treatment. Welch, W.J., Suhan, J.P. J. Cell Biol. (1985) [Pubmed]
  24. Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine. Lischwe, M.A., Ochs, R.L., Reddy, R., Cook, R.G., Yeoman, L.C., Tan, E.M., Reichlin, M., Busch, H. J. Biol. Chem. (1985) [Pubmed]
  25. Amino acids and control of nucleolar size, the activity of RNA polymerase I, and DNA synthesis in liver. Bailey, R.P., Vrooman, M.J., Sawai, Y., Tsukada, K., Short, J., Lieberman, I. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  26. Nucleolar protein B23 translocation after doxorubicin treatment in murine tumor cells. Chan, P.K., Aldrich, M.B., Yung, B.Y. Cancer Res. (1987) [Pubmed]
  27. Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats by flavonoids diosmin and hesperidin, each alone and in combination. Tanaka, T., Makita, H., Ohnishi, M., Mori, H., Satoh, K., Hara, A., Sumida, T., Fukutani, K., Tanaka, T., Ogawa, H. Cancer Res. (1997) [Pubmed]
  28. Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro. Jans, D.A., Jans, P., Briggs, L.J., Sutton, V., Trapani, J.A. J. Biol. Chem. (1996) [Pubmed]
  29. Expression of the transcriptional repressor protein Kid-1 leads to the disintegration of the nucleolus. Huang, Z., Philippin, B., O'Leary, E., Bonventre, J.V., Kriz, W., Witzgall, R. J. Biol. Chem. (1999) [Pubmed]
  30. Mapping a nucleolar targeting sequence of an RNA binding nucleolar protein, Nop25. Fujiwara, T., Suzuki, S., Kanno, M., Sugiyama, H., Takahashi, H., Tanaka, J. Exp. Cell Res. (2006) [Pubmed]
  31. Progressive growth of rat bladder carcinomas after exposure to prolonged uracil-induced urolithiasis. Shibata, M.A., Shirai, T., Takahashi, S., Takesada, Y., Iwata, H., Okumura, M., Fukushima, S. Teratog., Carcinog. Mutagen. (1994) [Pubmed]
  32. Growth hormone regulates nucleolar organizer regions during odontogenesis in the rat. Zhang, C.Z., Young, W.G., Li, H., Rolinson, S., Waters, M.J. J. Oral Pathol. Med. (1992) [Pubmed]
  33. Jun, Fos and Krox in the thalamus after C-fiber stimulation: coincident-input-dependent expression, expression across somatotopic boundaries, and nucleolar translocation. Pearse, D.D., Bushell, G., Leah, J.D. Neuroscience (2001) [Pubmed]
  34. Molecular cloning and functional expression of nucleolar phospholipid hydroperoxide glutathione peroxidase in mammalian cells. Nakamura, T., Imai, H., Tsunashima, N., Nakagawa, Y. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  35. Nucleolar localization of hepatic c-Myc: a potential mechanism for c-Myc regulation. Sanders, J.A., Gruppuso, P.A. Biochim. Biophys. Acta (2005) [Pubmed]
  36. Antibodies to a nucleolar protein are localized in the nucleolus after red blood cell-mediated microinjection. Bennett, F.C., Busch, H., Lischwe, M.A., Yeoman, L.C. J. Cell Biol. (1983) [Pubmed]
  37. Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. Kawamori, T., Tanaka, T., Hara, A., Yamahara, J., Mori, H. Cancer Res. (1995) [Pubmed]
  38. A nuclear localization signal binding protein in the nucleolus. Meier, U.T., Blobel, G. J. Cell Biol. (1990) [Pubmed]
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