High impact information on TXNDC12

• Furthermore, in vitro ERp18 possesses significant peptide thiol-disulfide oxidase activity, which is dependent on the presence of both active site cysteine residues [1].
• We show that ERp18 is located in the endoplasmic reticulum and that it contains a single catalytic domain with an unusual CGAC active site motif and a probable insertion between beta3 and alpha3 of the thioredoxin fold [1].
• Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein [2].
• By comparing full-length cDNA with human genomic DNA, the hTLP19 gene might have seven coding exons spanning 35 kb of genomic DNA on the human chromosome 1p32 [2].
• A novel human gene, named as hTLP19, was isolated and characterized as secretory protein by combining bioinformatics tools with experiments [2].

Biological context of TXNDC12

• From circular dichroism and NMR measurements, ERp18 is well structured and undergoes only a minor conformational change upon dithioldisulfide exchange in the active site [1].

Analytical, diagnostic and therapeutic context of TXNDC12

• 3. Northern blot analysis showed that human hTLP19 is expressed widely in many tissues with 1.6 kb band and extra 1.2 kb band in placenta [2].

References