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Gene Review

SDF4  -  stromal cell derived factor 4

Homo sapiens

Synonyms: 45 kDa calcium-binding protein, CAB45, Cab45, PSEC0034, SDF-4, ...
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High impact information on SDF4

  • Cab45 is ubiquitously expressed, contains an NH2-terminal signal sequence but no membrane-anchor sequences, and binds Ca2+ due to the presence of six EF-hand motifs [1].
  • We have identified and characterized Cab45, a novel 45-kD protein from mouse 3T3-L1 adipocytes [1].
  • In contrast to reticulocalbin and ERC-55 which are soluble components of the endoplasmic reticulum, Cab45 is a soluble protein localized to the Golgi [1].
  • Calumenin belongs to a family of multiple EF-hand proteins that include reticulocalbin, ERC-55, and Cab45 [2].
  • Cab45 contains a HEEF C-terminal sequence and is localized to the Golgi apparatus [2].

Biological context of SDF4

  • Sequence of a human cDNA encoding Cab45, a Ca2+-binding protein with six EF-hand motifs [3].

Anatomical context of SDF4

  • The protein is a likely human counterpart of the Cab45 protein recently identified in the 3T3-L1 mouse adipocyte cell line [Scherer et al. (1996), J. Cell Biol. 133, 257-268], displaying 87% aa and 83% nt identity with this sequence [3].

Other interactions of SDF4

  • RCN-3 is a member of the CREC (Cab45/reticulocalbin/ERC45/calumenin) family of multiple EF-hand Ca2+-binding proteins localized to the secretory pathway [4].
  • Calumenin belongs to a family of multiple EF-hand proteins that include the ER localized proteins reticulocalbin and ERC-55 and the Golgi localized Cab45 [5].

Analytical, diagnostic and therapeutic context of SDF4


  1. Cab45, a novel (Ca2+)-binding protein localized to the Golgi lumen. Scherer, P.E., Lederkremer, G.Z., Williams, S., Fogliano, M., Baldini, G., Lodish, H.F. J. Cell Biol. (1996) [Pubmed]
  2. Human calumenin localizes to the secretory pathway and is secreted to the medium. Vorum, H., Hager, H., Christensen, B.M., Nielsen, S., Honoré, B. Exp. Cell Res. (1999) [Pubmed]
  3. Sequence of a human cDNA encoding Cab45, a Ca2+-binding protein with six EF-hand motifs. Koivu, T., Laitinen, S., Riento, K., Olkkonen, V.M. DNA Seq. (1997) [Pubmed]
  4. A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4. Tsuji, A., Kikuchi, Y., Sato, Y., Koide, S., Yuasa, K., Nagahama, M., Matsuda, Y. Biochem. J. (2006) [Pubmed]
  5. Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity. Vorum, H., Liu, X., Madsen, P., Rasmussen, H.H., Honoré, B. Biochim. Biophys. Acta (1998) [Pubmed]
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