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Gene Review

RCN2  -  reticulocalbin 2, EF-hand calcium binding...

Homo sapiens

Synonyms: Calcium-binding protein ERC-55, E6-binding protein, E6BP, ERC-55, ERC55, ...
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High impact information on RCN2


Biological context of RCN2


Other interactions of RCN2

  • Calumenin belongs to a family of multiple EF-hand proteins that include the ER localized proteins reticulocalbin and ERC-55 and the Golgi localized Cab45 [6].
  • The predicted C-terminal region also appears to contain a sixth EF-hand calcium-binding domain, which suggests that PfERC is related to previously reported ER-localized calcium-binding proteins, namely reticulocalbin and ERC-55 (Ozawa M. J. Biochem. 1995;117:1113-1119; Weis K, Griffiths G, Lamond AI. J. Biol. Chem. 1994;269:19142-19150) [7].

Analytical, diagnostic and therapeutic context of RCN2

  • Comparative sequence analysis indicates that ERC-55, together with the recently identified protein reticulocalbin (Ozawa and Muramatsu, 1993), constitute a new subfamily of the EF-hand superfamily of Ca(2+)-binding proteins that are specifically located in the ER [2].
  • We mapped mutants with moderate activity in the biological assay that lacked the ability to bind to E6BP and a mutant that showed high biological activity with only marginal binding to E6BP [8].


  1. Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. Chen, J.J., Reid, C.E., Band, V., Androphy, E.J. Science (1995) [Pubmed]
  2. The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif. Weis, K., Griffiths, G., Lamond, A.I. J. Biol. Chem. (1994) [Pubmed]
  3. Mutational analysis of transcriptional activation by the bovine papillomavirus type 1 E6. Chen, J.J., Hong, Y., Androphy, E.J. Virology (1997) [Pubmed]
  4. Assignment of the gene for ERC-55 (RCN2) to human chromosome band 15q22.33-->q24.1 by in situ hybridization. Wang, J.Y., Zhen, D.K., Bianchi, D.W., Androphy, E.J., Chen, J.J. Cytogenet. Cell Genet. (1997) [Pubmed]
  5. Molecular characterisation of the t(1;15)(p22;q22) translocation in the prostate cancer cell line LNCaP. Strefford, J.C., Lane, T.M., Hill, A., LeRoux, L., Foot, N.J., Shipley, J., Oliver, R.T., Lu, Y.J., Young, B.D. Cytogenet. Genome Res. (2006) [Pubmed]
  6. Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity. Vorum, H., Liu, X., Madsen, P., Rasmussen, H.H., Honoré, B. Biochim. Biophys. Acta (1998) [Pubmed]
  7. Identification of an endoplasmic reticulum-resident calcium-binding protein with multiple EF-hand motifs in asexual stages of Plasmodium falciparum. La Greca, N., Hibbs, A.R., Riffkin, C., Foley, M., Tilley, L. Mol. Biochem. Parasitol. (1997) [Pubmed]
  8. Inhibition of serum- and calcium-induced terminal differentiation of human keratinocytes by HPV 16 E6: study of the association with p53 degradation, inhibition of p53 transactivation, and binding to E6BP. Sherman, L., Itzhaki, H., Jackman, A., Chen, J.J., Koval, D., Schlegel, R. Virology (2002) [Pubmed]
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