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Gene Review

CALU  -  calumenin

Homo sapiens

Synonyms: Calumenin, Crocalbin, IEF SSP 9302
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Disease relevance of CALU

  • The findings indicate that calumenin may participate in the immunological defense system and could be involved in the pathological process of amyloidosis that leads to formation of amyloid deposits seen in different types of tissues [1].
  • Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity [2].
  • To define the role of macrophage-tumor cell interaction with respect to angiogenesis, human peripheral blood monocytes (PBM) were cocultured with A549 (human bronchoalveolar cell carcinoma) or Calu 6 (human anaplastic carcinoma) NSCLC cells [3].
  • Our study thus indicates that calumenin may have an autocrine or a paracrine effect on the cells in its vicinity, and, therefore, may be involved in the pathophysiology of thrombosis or in wound healing [4].
  • Several established cell lines derived from human lung carcinomas (SK-LU-1, Calu -1, SK-MES-1 and A-549) show a uniform pattern of cytokeratin polypeptides (nos. 7, 8, 18 and 19), similar to that found in adenocarcinomas [5].

High impact information on CALU


Biological context of CALU


Anatomical context of CALU


Associations of CALU with chemical compounds

  • A single patient, homozygous for G(11)A CALU mutant allele, required an exceptionally high warfarin dose (20 mg/day) and the prevalence of heterozygous (11)A allele carriers in the upper 10(th) dose percentile was significantly higher (0.27 vs. 0.18, p < 0.02) [12].
  • Identification of hox genes and analysis of their transcription in the unicellular cyanobacterium Gloeocapsa alpicola CALU 743 growing under nitrate-limiting conditions [13].
  • After application of a placental tissue extract we were able to elute one protein that interacts with calumenin in the presence of Ca(2+) [1].

Physical interactions of CALU


Analytical, diagnostic and therapeutic context of CALU

  • Since its Ca2+ binding may be important for the function of the protein we have used microdialysis experiments in order to analyse for the affinity and the capacity of recombinant human (rh) calumenin [2].


  1. Calumenin interacts with serum amyloid P component. Vorum, H., Jacobsen, C., Honoré, B. FEBS Lett. (2000) [Pubmed]
  2. Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity. Vorum, H., Liu, X., Madsen, P., Rasmussen, H.H., Honoré, B. Biochim. Biophys. Acta (1998) [Pubmed]
  3. Non-small cell lung cancer cells induce monocytes to increase expression of angiogenic activity. White, E.S., Strom, S.R., Wys, N.L., Arenberg, D.A. J. Immunol. (2001) [Pubmed]
  4. Proteomic profiling of fibroblasts reveals a modulating effect of extracellular calumenin on the organization of the actin cytoskeleton. Ostergaard, M., Hansen, G.A., Vorum, H., Honoré, B. Proteomics (2006) [Pubmed]
  5. Cytokeratins in normal lung and lung carcinomas. I. Adenocarcinomas, squamous cell carcinomas and cultured cell lines. Blobel, G.A., Moll, R., Franke, W.W., Vogt-Moykopf, I. Virchows Arch., B, Cell Pathol. (1984) [Pubmed]
  6. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Coppinger, J.A., Cagney, G., Toomey, S., Kislinger, T., Belton, O., McRedmond, J.P., Cahill, D.J., Emili, A., Fitzgerald, D.J., Maguire, P.B. Blood (2004) [Pubmed]
  7. Human calumenin localizes to the secretory pathway and is secreted to the medium. Vorum, H., Hager, H., Christensen, B.M., Nielsen, S., Honoré, B. Exp. Cell Res. (1999) [Pubmed]
  8. Polymorphisms in Vitamin K-Dependent gamma-Carboxylation-Related Genes Influence Interindividual Variability in Plasma Protein C and Protein S Activities in the General Population. Kimura, R., Kokubo, Y., Miyashita, K., Otsubo, R., Nagatsuka, K., Otsuki, T., Sakata, T., Nagura, J., Okayama, A., Minematsu, K., Naritomi, H., Honda, S., Sato, K., Tomoike, H., Miyata, T. Int. J. Hematol. (2006) [Pubmed]
  9. Crocalbin: a new calcium-binding protein that is also a binding protein for crotoxin, a neurotoxic phospholipase A2. Hseu, M.J., Yen, C.H., Tzeng, M.C. FEBS Lett. (1999) [Pubmed]
  10. Keratinocyte growth factor accelerates wound closure in airway epithelium during cyclic mechanical strain. Waters, C.M., Savla, U. J. Cell. Physiol. (1999) [Pubmed]
  11. Anion selectivity of apical membrane conductance of Calu 3 human airway epithelium. Illek, B., Tam, A.W., Fischer, H., Machen, T.E. Pflugers Arch. (1999) [Pubmed]
  12. Combined genetic profiles of components and regulators of the vitamin K-dependent gamma-carboxylation system affect individual sensitivity to warfarin. Vecsler, M., Loebstein, R., Almog, S., Kurnik, D., Goldman, B., Halkin, H., Gak, E. Thromb. Haemost. (2006) [Pubmed]
  13. Identification of hox genes and analysis of their transcription in the unicellular cyanobacterium Gloeocapsa alpicola CALU 743 growing under nitrate-limiting conditions. Sheremetieva, M.E., Troshina, O.Y., Serebryakova, L.T., Lindblad, P. FEMS Microbiol. Lett. (2002) [Pubmed]
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