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Gene Review

NUSAP1  -  nucleolar and spindle associated protein 1

Homo sapiens

Synonyms: ANKT, BM-037, BM037, FLJ13421, LNP, ...
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High impact information on NUSAP1


Biological context of NUSAP1

  • We propose that the presence of MT binding agents such as NuSAP, which can be directly immobilized on chromatin, are critical for targeting MT production to vertebrate chromosomes during spindle self-organization [2].
  • Each mutagenic codon cassette contains a three base pair direct terminal repeat and two head-to-head recognition sequences for the restriction endonuclease Sapl, an enzyme that cleaves outside of its recognition sequence [3].

Anatomical context of NUSAP1

  • These results suggest a crucial role for NuSAP in spindle microtubule organization [1].

Associations of NUSAP1 with chemical compounds


Other interactions of NUSAP1

  • RanGTP is generated at chromatin and activates a set of soluble, Ran-regulated spindle factors such as TPX2, NuMA, and NuSAP . How the spindle factors direct and attach MTs to the chromosomes are key open questions [2].


  1. NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. Raemaekers, T., Ribbeck, K., Beaudouin, J., Annaert, W., Van Camp, M., Stockmans, I., Smets, N., Bouillon, R., Ellenberg, J., Carmeliet, G. J. Cell Biol. (2003) [Pubmed]
  2. A Role for NuSAP in Linking Microtubules to Mitotic Chromosomes. Ribbeck, K., Raemaekers, T., Carmeliet, G., Mattaj, I.W. Curr. Biol. (2007) [Pubmed]
  3. Codon cassette mutagenesis: a general method to insert or replace individual codons by using universal mutagenic cassettes. Kegler-Ebo, D.M., Docktor, C.M., DiMaio, D. Nucleic Acids Res. (1994) [Pubmed]
  4. Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis and Candida lusitaniae. Inhibition with peptidomimetic inhibitors. Pichová, I., Pavlícková, L., Dostál, J., Dolejsí, E., Hrusková-Heidingsfeldová, O., Weber, J., Ruml, T., Soucek, M. Eur. J. Biochem. (2001) [Pubmed]
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