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Gene Review

Fbl  -  fibrillarin

Mus musculus

Synonyms: AL022665, FIB, FLRN, Histone-glutamine methyltransferase, Nucleolar protein 1, ...
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Disease relevance of Fbl


Psychiatry related information on Fbl

  • Since nuclear tau has also been found in neurons from patients with Alzheimer's disease (AD), aberrant nuclear tau could affect the nucleolar organization during the course of AD [6].

High impact information on Fbl

  • In exploring the mechanism by which the active or silent state of rRNA genes is inherited, we found that NoRC, a nucleolar remodeling complex containing Snf2h (also called Smarca5, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin, subfamily a, member 5), represses rDNA transcription [7].
  • Transient transfection studies with PHF6 tagged with green fluorescent protein (GFP) showed diffuse nuclear staining with prominent nucleolar accumulation [8].
  • Here, we demonstrate that two major nucleolar proteins, nucleolin and NO38, are highly phosphorylated during mitosis [9].
  • These results identify two novel candidate substrates for cdc2 kinase, and they implicate protein phosphorylation in controlling mitotic changes in nucleolar structure and activity [9].
  • Our unexpected results suggest a role for these major nucleolar proteins in the nucleocytoplasmic transport of ribosomal components [10].

Chemical compound and disease context of Fbl


Biological context of Fbl


Anatomical context of Fbl


Associations of Fbl with chemical compounds


Other interactions of Fbl


Analytical, diagnostic and therapeutic context of Fbl


  1. Effect of dexamethasone on nucleolar casein kinase II activity and phosphorylation of nucleolin in lymphosarcoma P1798 cells. Suzuki, N., Suzuki, T., Uchida, A., Thompson, E.A., Hosoya, T. J. Steroid Biochem. Mol. Biol. (1992) [Pubmed]
  2. Autoantibody to U3 nucleolar ribonucleoprotein (fibrillarin) in patients with systemic sclerosis. Okano, Y., Steen, V.D., Medsger, T.A. Arthritis Rheum. (1992) [Pubmed]
  3. Interaction of the coronavirus nucleoprotein with nucleolar antigens and the host cell. Chen, H., Wurm, T., Britton, P., Brooks, G., Hiscox, J.A. J. Virol. (2002) [Pubmed]
  4. Mercuric chloride induces autoantibodies against U3 small nuclear ribonucleoprotein in susceptible mice. Reuter, R., Tessars, G., Vohr, H.W., Gleichmann, E., Lührmann, R. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  5. Heterogeneity of subcellular localization and electrophoretic mobility of survival motor neuron (SMN) protein in mammalian neural cells and tissues. Francis, J.W., Sandrock, A.W., Bhide, P.G., Vonsattel, J.P., Brown, R.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization. Sjöberg, M.K., Shestakova, E., Mansuroglu, Z., Maccioni, R.B., Bonnefoy, E. J. Cell. Sci. (2006) [Pubmed]
  7. The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Santoro, R., Li, J., Grummt, I. Nat. Genet. (2002) [Pubmed]
  8. Mutations in PHF6 are associated with Börjeson-Forssman-Lehmann syndrome. Lower, K.M., Turner, G., Kerr, B.A., Mathews, K.D., Shaw, M.A., Gedeon, A.K., Schelley, S., Hoyme, H.E., White, S.M., Delatycki, M.B., Lampe, A.K., Clayton-Smith, J., Stewart, H., van Ravenswaay, C.M., de Vries, B.B., Cox, B., Grompe, M., Ross, S., Thomas, P., Mulley, J.C., Gécz, J. Nat. Genet. (2002) [Pubmed]
  9. Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase. Peter, M., Nakagawa, J., Dorée, M., Labbé, J.C., Nigg, E.A. Cell (1990) [Pubmed]
  10. Major nucleolar proteins shuttle between nucleus and cytoplasm. Borer, R.A., Lehner, C.F., Eppenberger, H.M., Nigg, E.A. Cell (1989) [Pubmed]
  11. Cyclosporin A and verapamil enhancement of daunorubicin-produced nucleolar protein B23 translocation in daunorubicin-resistant and -sensitive human and murine tumor cells. Sweet, P., Chan, P.K., Slater, L.M. Cancer Res. (1989) [Pubmed]
  12. Urinary mercury levels in patients with autoantibodies to U3-RNP (fibrillarin). Arnett, F.C., Fritzler, M.J., Ahn, C., Holian, A. J. Rheumatol. (2000) [Pubmed]
  13. Changes in nucleolar number of ascites tumor cells treated with actinomycin D. Gyeskó, A., Holczinger, L. Neoplasma (1975) [Pubmed]
  14. High-resolution autoradiographic study on the presence of chromatin structures within interchromatin granule conglomerations. Gruca, S., Krzyzowska-Gruca, S., Zborek, A. Acta Histochem. (1981) [Pubmed]
  15. Effects of dibutyryl cyclic adenosine monophosphate on nucleolar organizer regions and epidermal growth factor receptor of Dunn osteosarcoma cells. Kanamori, M., Matsui, H., Yudoh, K., Maeda, A., Tsuji, H. J. Exp. Clin. Cancer Res. (1997) [Pubmed]
  16. Implication of Nucleolar Protein SURF6 in Ribosome Biogenesis and Preimplantation Mouse Development. Romanova, L.G., Anger, M., Zatsepina, O.V., Schultz, R.M. Biol. Reprod. (2006) [Pubmed]
  17. Fibrillarin is essential for early development and required for accumulation of an intron-encoded small nucleolar RNA in the mouse. Newton, K., Petfalski, E., Tollervey, D., Cáceres, J.F. Mol. Cell. Biol. (2003) [Pubmed]
  18. Subcellular recruitment of fibrillarin to nucleoplasmic proteasomes: implications for processing of a nucleolar autoantigen. Chen, M., Rockel, T., Steinweger, G., Hemmerich, P., Risch, J., von Mikecz, A. Mol. Biol. Cell (2002) [Pubmed]
  19. Nucleolar substructures of rabbit cleaving embryos: an immunocytochemical study. Baran, V., Mercier, Y., Renard, J.P., Fléchon, J.E. Mol. Reprod. Dev. (1997) [Pubmed]
  20. Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product. Tucker, K.E., Berciano, M.T., Jacobs, E.Y., LePage, D.F., Shpargel, K.B., Rossire, J.J., Chan, E.K., Lafarga, M., Conlon, R.A., Matera, A.G. J. Cell Biol. (2001) [Pubmed]
  21. Localization of fibrillarin and nucleolin in nucleoli of mouse preimplantation embryos. Baran, V., Veselá, J., Rehák, P., Koppel, J., Fléchon, J.E. Mol. Reprod. Dev. (1995) [Pubmed]
  22. Ultrastructural morphometrical and immunocytochemical analyses of hepatocyte nuclei from mice fed on genetically modified soybean. Malatesta, M., Caporaloni, C., Gavaudan, S., Rocchi, M.B., Serafini, S., Tiberi, C., Gazzanelli, G. Cell Struct. Funct. (2002) [Pubmed]
  23. The biogenesis of the coiled body during early mouse development. Ferreira, J., Carmo-Fonseca, M. Development (1995) [Pubmed]
  24. Determination of the functional domains involved in nucleolar targeting of nucleolin. Créancier, L., Prats, H., Zanibellato, C., Amalric, F., Bugler, B. Mol. Biol. Cell (1993) [Pubmed]
  25. Yeast NPI46 encodes a novel prolyl cis-trans isomerase that is located in the nucleolus. Shan, X., Xue, Z., Mélèse, T. J. Cell Biol. (1994) [Pubmed]
  26. Insulin induces the phosphorylation of nucleolin. A possible mechanism of insulin-induced RNA efflux from nuclei. Csermely, P., Schnaider, T., Cheatham, B., Olson, M.O., Kahn, C.R. J. Biol. Chem. (1993) [Pubmed]
  27. Immunohistochemical studies of cyclic guanosine monophosphate and nuclear function. Rosenberg, E.M., Conway, J.G., Tucci, S.M., Doucet, E.W. J. Clin. Invest. (1980) [Pubmed]
  28. In vivo kinetics of Cajal body components. Dundr, M., Hebert, M.D., Karpova, T.S., Stanek, D., Xu, H., Shpargel, K.B., Meier, U.T., Neugebauer, K.M., Matera, A.G., Misteli, T. J. Cell Biol. (2004) [Pubmed]
  29. Nuclear DNA helicase II (RNA helicase A) binds to an F-actin containing shell that surrounds the nucleolus. Zhang, S., Köhler, C., Hemmerich, P., Grosse, F. Exp. Cell Res. (2004) [Pubmed]
  30. Identification of nucleolin as a binding protein for midkine (MK) and heparin-binding growth associated molecule (HB-GAM). Take, M., Tsutsui, J., Obama, H., Ozawa, M., Nakayama, T., Maruyama, I., Arima, T., Muramatsu, T. J. Biochem. (1994) [Pubmed]
  31. Distribution of nucleolar proteins B23 and nucleolin during mouse spermatogenesis. Biggiogera, M., Kaufmann, S.H., Shaper, J.H., Gas, N., Amalric, F., Fakan, S. Chromosoma (1991) [Pubmed]
  32. Development-dependent localization of nuclear antigens in growing mouse oocytes. Borsuk, E., Vautier, D., Szöllösi, M.S., Besombes, D., Debey, P. Mol. Reprod. Dev. (1996) [Pubmed]
  33. Molecular cloning and sequence analysis of U3 snoRNA-associated mouse fibrillarin. Turley, S.J., Tan, E.M., Pollard, K.M. Biochim. Biophys. Acta (1993) [Pubmed]
  34. Immunocytochemical localisation of the nucleolar protein fibrillarin and RNA polymerase I during mouse early embryogenesis. Cuadros-Fernández, J.M., Esponda, P. Zygote (1996) [Pubmed]
  35. Nucleolar distribution of proteins B23 and nucleolin in mouse preimplantation embryos as visualized by immunoelectron microscopy. Biggiogera, M., Bürki, K., Kaufmann, S.H., Shaper, J.H., Gas, N., Amalric, F., Fakan, S. Development (1990) [Pubmed]
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