Gene Review:
TPX2 - TPX2, microtubule-associated
Homo sapiens
Synonyms:
C20orf1, C20orf2, DIL-2, DIL2, Differentially expressed in cancerous and non-cancerous lung cells 2, ...
- Expression of targeting protein for xklp2 associated with both malignant transformation of respiratory epithelium and progression of squamous cell lung cancer. Ma, Y., Lin, D., Sun, W., Xiao, T., Yuan, J., Han, N., Guo, S., Feng, X., Su, K., Mao, Y., Cheng, S., Gao, Y. Clin. Cancer Res. (2006)
- High-resolution genomic profiles of human lung cancer. Tonon, G., Wong, K.K., Maulik, G., Brennan, C., Feng, B., Zhang, Y., Khatry, D.B., Protopopov, A., You, M.J., Aguirre, A.J., Martin, E.S., Yang, Z., Ji, H., Chin, L., Depinho, R.A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity. Gruss, O.J., Carazo-Salas, R.E., Schatz, C.A., Guarguaglini, G., Kast, J., Wilm, M., Le Bot, N., Vernos, I., Karsenti, E., Mattaj, I.W. Cell (2001)
- Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Sessa, F., Mapelli, M., Ciferri, C., Tarricone, C., Areces, L.B., Schneider, T.R., Stukenberg, P.T., Musacchio, A. Mol. Cell (2005)
- Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Bayliss, R., Sardon, T., Vernos, I., Conti, E. Mol. Cell (2003)
- Genetic polymorphism of human herpesvirus-7 among human populations. Franti, M., Gessain, A., Darlu, P., Gautheret-Dejean, A., Kosuge, H., Mauclère, P., Aubin, J.T., Gurtsevitch, V., Yamanishi, K., Agut, H. J. Gen. Virol. (2001)
- A protein kinase C-independent pathway leading to c-Jun-dependent expression of 100-kDa Ras GTPase-activating protein in JEG-3 human choriocarcinoma cells. Ye, F., Bourgeade, M.F., Cayre, Y.E., Thang, M.N. Eur. J. Biochem. (2000)
- The superior prognostic value of humoral factors compared with molecular proliferation markers in renal cell carcinoma. Lehmann, J., Retz, M., Nürnberg, N., Schnöckel, U., Raffenberg, U., Krams, M., Kellner, U., Siemer, S., Weichert-Jacobsen, K., Stöckle, M. Cancer (2004)
- Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. Manda, R., Kohno, T., Matsuno, Y., Takenoshita, S., Kuwano, H., Yokota, J. Genomics (1999)
- Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells. Gruss, O.J., Wittmann, M., Yokoyama, H., Pepperkok, R., Kufer, T., Silljé, H., Karsenti, E., Mattaj, I.W., Vernos, I. Nat. Cell Biol. (2002)
- Importin beta is transported to spindle poles during mitosis and regulates Ran-dependent spindle assembly factors in mammalian cells. Ciciarello, M., Mangiacasale, R., Thibier, C., Guarguaglini, G., Marchetti, E., Di Fiore, B., Lavia, P. J. Cell. Sci. (2004)
- Human TPX2 is required for targeting Aurora-A kinase to the spindle. Kufer, T.A., Silljé, H.H., Körner, R., Gruss, O.J., Meraldi, P., Nigg, E.A. J. Cell Biol. (2002)
- Critical role of RelB serine 368 for dimerization and p100 stabilization. Maier, H.J., Marienfeld, R., Wirth, T., Baumann, B. J. Biol. Chem. (2003)
- Regulation of NF-kappa B2 p100 processing by its cis-acting domain. Qing, G., Qu, Z., Xiao, G. J. Biol. Chem. (2005)
- Avian oncovirus MH2: molecular cloning of proviral DNA and structural analysis of viral RNA and protein. Jansen, H.W., Patschinsky, T., Bister, K. J. Virol. (1983)
- Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit. Stewart, S., Fang, G. Mol. Cell. Biol. (2005)
- p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. Heidebrecht, H.J., Buck, F., Steinmann, J., Sprenger, R., Wacker, H.H., Parwaresch, R. Blood (1997)
- TPX2, A novel xenopus MAP involved in spindle pole organization. Wittmann, T., Wilm, M., Karsenti, E., Vernos, I. J. Cell Biol. (2000)
- Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity. Maxwell, C.A., Keats, J.J., Belch, A.R., Pilarski, L.M., Reiman, T. Cancer Res. (2005)
- 20q11.1 amplification in giant-cell tumor of bone: Array CGH, FISH, and association with outcome. Smith, L.T., Mayerson, J., Nowak, N.J., Suster, D., Mohammed, N., Long, S., Auer, H., Jones, S., McKeegan, C., Young, G., Bos, G., Plass, C., Morrison, C. Genes Chromosomes Cancer (2006)
- Assignment of human proliferation associated p100 gene (C20orf1) to human chromosome band 20q11.2 by in situ hybridization. Zhang, Y., Heidebrecht, H., Rott, A., Schlegelberger, B., Parwaresch, R. Cytogenet. Cell Genet. (1999)
- Expression and function of a variant T cell receptor complex lacking CD3-gamma. Pérez-Aciego, P., Alarcón, B., Arnaiz-Villena, A., Terhorst, C., Timón, M., Segurado, O.G., Regueiro, J.R. J. Exp. Med. (1991)