Disease relevance of CD320

• In addition, the mAb 8D6 inhibits the growth of a lymphoma of GC origin, L3055, which depends on FDCs or HK cells for its growth [1].
• Novel follicular dendritic cell molecule, 8D6, collaborates with CD44 in supporting lymphomagenesis by a Burkitt lymphoma cell line, L3055 [2].

High impact information on CD320

• The inhibitory activity of the mAb 8D6 was demonstrated to be due to an inhibition of cell cycle progression of CD40 ligand-stimulated GC B cells [1].
• Monolayers of COS cells transiently transfected with the 8D6 Ag cDNA stimulate B cell growth [1].
• FDC-SM-8D6 enhances L3055 cell proliferation, whereas FDC-SM-4G10/CD44 inhibits its apoptosis [2].
• COS cells expressing FDC-SM-8D6 enhanced GC-B cell proliferation and Ab secretion, which was blocked by mAb 8D6 [3].
• The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation [3].

Biological context of CD320

• The 8D6 antibody did not have direct effects on T-cell activation or apoptosis, and the function of CD147 in development and activation of T cells is not yet clear [4].

Anatomical context of CD320

• FDC-SM-8D6-specific mAb blocked PC generation and IgG secretion but not memory B cell proliferation [3].

References