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MeSH Review

Dendritic Cells, Follicular

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Disease relevance of Dendritic Cells, Follicular


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Biological context of Dendritic Cells, Follicular


Anatomical context of Dendritic Cells, Follicular


Associations of Dendritic Cells, Follicular with chemical compounds


Gene context of Dendritic Cells, Follicular


Analytical, diagnostic and therapeutic context of Dendritic Cells, Follicular

  • The molecule CD200 (previously called OX2), associated with, among others, follicular dendritic cells, is implicated in delivery of immunosuppressive signals to the immune system, and an immunoadhesin in which the extracellular domains of CD200 were linked to a mouse IgG2a Fc region has been shown to promote renal allograft survival [30].


  1. Complement facilitates early prion pathogenesis. Klein, M.A., Kaeser, P.S., Schwarz, P., Weyd, H., Xenarios, I., Zinkernagel, R.M., Carroll, M.C., Verbeek, J.S., Botto, M., Walport, M.J., Molina, H., Kalinke, U., Acha-Orbea, H., Aguzzi, A. Nat. Med. (2001) [Pubmed]
  2. Immunologically induced, complement-dependent up-regulation of the prion protein in the mouse spleen: follicular dendritic cells versus capsule and trabeculae. Lötscher, M., Recher, M., Hunziker, L., Klein, M.A. J. Immunol. (2003) [Pubmed]
  3. Follicular dendritic cell contributions to HIV pathogenesis. Burton, G.F., Keele, B.F., Estes, J.D., Thacker, T.C., Gartner, S. Semin. Immunol. (2002) [Pubmed]
  4. CD10 and BCL6 expression in the diagnosis of angioimmunoblastic T-cell lymphoma: utility of detecting CD10+ T cells by flow cytometry. Yuan, C.M., Vergilio, J.A., Zhao, X.F., Smith, T.K., Harris, N.L., Bagg, A. Hum. Pathol. (2005) [Pubmed]
  5. Alterations in fascin-expressing germinal center dendritic cells in neoplastic follicles of B-cell lymphomas. Said, J.W., Pinkus, J.L., Shintaku, I.P., deVos, S., Matsumura, F., Yamashiro, S., Pinkus, G.S. Mod. Pathol. (1998) [Pubmed]
  6. Species barrier prevents an abnormal isoform of prion protein from accumulating in follicular dendritic cells of mice with Creutzfeldt-Jakob disease. Muramoto, T., Kitamoto, T., Hoque, M.Z., Tateishi, J., Goto, I. J. Virol. (1993) [Pubmed]
  7. A chemokine-driven positive feedback loop organizes lymphoid follicles. Ansel, K.M., Ngo, V.N., Hyman, P.L., Luther, S.A., Förster, R., Sedgwick, J.D., Browning, J.L., Lipp, M., Cyster, J.G. Nature (2000) [Pubmed]
  8. Negative feedback regulation of IgE synthesis by murine CD23. Yu, P., Kosco-Vilbois, M., Richards, M., Köhler, G., Lamers, M.C. Nature (1994) [Pubmed]
  9. Induction of secondary and tertiary lymphoid structures in the skin. Cupedo, T., Jansen, W., Kraal, G., Mebius, R.E. Immunity (2004) [Pubmed]
  10. Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. Ahearn, J.M., Fischer, M.B., Croix, D., Goerg, S., Ma, M., Xia, J., Zhou, X., Howard, R.G., Rothstein, T.L., Carroll, M.C. Immunity (1996) [Pubmed]
  11. Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice. Rahman, Z.S., Rao, S.P., Kalled, S.L., Manser, T. J. Exp. Med. (2003) [Pubmed]
  12. Sonic hedgehog is produced by follicular dendritic cells and protects germinal center B cells from apoptosis. Sacedón, R., Díez, B., Nuñez, V., Hernández-López, C., Gutierrez-Frías, C., Cejalvo, T., Outram, S.V., Crompton, T., Zapata, A.G., Vicente, A., Varas, A. J. Immunol. (2005) [Pubmed]
  13. Antigen-driven selection of virgin and memory B cells. MacLennan, I.C., Gray, D. Immunol. Rev. (1986) [Pubmed]
  14. Transgenic expression of lymphotoxin restores lymph nodes to lymphotoxin-alpha-deficient mice. Sacca, R., Turley, S., Soong, L., Mellman, I., Ruddle, N.H. J. Immunol. (1997) [Pubmed]
  15. Abnormal CD4:CD8 ratios and delayed germinal center reconstitution in lymph nodes of human graft recipients with graft-versus-host disease (GVHD): an immunohistological study. Sale, G.E., Alavaikko, M., Schaefers, K.M., Mahan, C.T. Exp. Hematol. (1992) [Pubmed]
  16. Distinct roles of lymphotoxin alpha and the type I tumor necrosis factor (TNF) receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells. Matsumoto, M., Fu, Y.X., Molina, H., Huang, G., Kim, J., Thomas, D.A., Nahm, M.H., Chaplin, D.D. J. Exp. Med. (1997) [Pubmed]
  17. Staining of Langerhans cells with monoclonal antibodies to macrophages and lymphoid cells. Haines, K.A., Flotte, T.J., Springer, T.A., Gigli, I., Thorbecke, G.J. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  18. Tumor necrosis factor receptor-associated factor 1 is overexpressed in Reed-Sternberg cells of Hodgkin's disease and Epstein-Barr virus-transformed lymphoid cells. Dürkop, H., Foss, H.D., Demel, G., Klotzbach, H., Hahn, C., Stein, H. Blood (1999) [Pubmed]
  19. Estrogen receptor alpha is a novel marker expressed by follicular dendritic cells in lymph nodes and tumor-associated lymphoid infiltrates. Sapino, A., Cassoni, P., Ferrero, E., Bongiovanni, M., Righi, L., Fortunati, N., Crafa, P., Chiarle, R., Bussolati, G. Am. J. Pathol. (2003) [Pubmed]
  20. Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer's patches. Tumanov, A.V., Kuprash, D.V., Mach, J.A., Nedospasov, S.A., Chervonsky, A.V. J. Immunol. (2004) [Pubmed]
  21. Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice. Pozdnyakova, O., Guttormsen, H.K., Lalani, F.N., Carroll, M.C., Kasper, D.L. J. Immunol. (2003) [Pubmed]
  22. A study of accessory cells in the acquired lymphoid tissue of helicobacter gastritis. Sarsfield, P., Jones, D.B., Wotherspoon, A.C., Harvard, T., Wright, D.H. J. Pathol. (1996) [Pubmed]
  23. The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues. Taylor, P.R., Pickering, M.C., Kosco-Vilbois, M.H., Walport, M.J., Botto, M., Gordon, S., Martinez-Pomares, L. Eur. J. Immunol. (2002) [Pubmed]
  24. IL-4 augments anisomycin-induced p38 activation via Akt pathway in a follicular dendritic cell (FDC)-like line. Lee, H.M., Jin, H.S., Park, J.W., Park, S.M., Jeon, H.K., Lee, T.H. FEBS Lett. (2003) [Pubmed]
  25. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. Endres, R., Alimzhanov, M.B., Plitz, T., Fütterer, A., Kosco-Vilbois, M.H., Nedospasov, S.A., Rajewsky, K., Pfeffer, K. J. Exp. Med. (1999) [Pubmed]
  26. Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells. Prinz, M., Montrasio, F., Klein, M.A., Schwarz, P., Priller, J., Odermatt, B., Pfeffer, K., Aguzzi, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  27. Follicular dendritic cells adhere to fibronectin and laminin fibers via their respective receptors. Ogata, T., Yamakawa, M., Imai, Y., Takahashi, T. Blood (1996) [Pubmed]
  28. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Serafini, B., Rosicarelli, B., Magliozzi, R., Stigliano, E., Aloisi, F. Brain Pathol. (2004) [Pubmed]
  29. Yin Yang 1, Oct1, and NFAT-4 form repeating, cyclosporin-sensitive regulatory modules within the murine CD21 intronic control region. Zabel, M.D., Wheeler, W., Weis, J.J., Weis, J.H. J. Immunol. (2002) [Pubmed]
  30. CD200 immunoadhesin suppresses collagen-induced arthritis in mice. Gorczynski, R.M., Chen, Z., Yu, K., Hu, J. Clin. Immunol. (2001) [Pubmed]
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