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Gene Review:

CYP39A1 - cytochrome P450, family 39, subfamily A,...

Homo sapiens

Synonyms: 24-hydroxycholesterol 7-alpha-hydroxylase, Cytochrome P450 39A1, Oxysterol 7-alpha-hydroxylase, hCYP39A1

Li-Hawkins, J. et al., Toll, A. et al., Ikeda, H. et al., Norlin, M. et al., Bodin, K. et al.

Norlin, Andersson, Björkhem, Wikvall,

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High impact information on CYP39A1

CYP7B1 and CYP39A1 had no activity toward 4 beta-hydroxycholesterol [1].
CYP39A1 is a microsomal cytochrome P450 enzyme that has preference for 24-hydroxycholesterol and is expressed in the liver [2].
The genes contain 12 exons and are located on chromosome 6 in the human (CYP39A1 locus) and in a syntenic position on chromosome 17 in the mouse (Cyp39a1 locus) [2].
Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A) [3].
Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye [4].

Biological context of CYP39A1

The amino acid sequence of this antigenic protein was identical to human CYP39A1 oxysterol 7alpha-hydroxylase [4].
Inhibition experiments with a partially purified fraction of the oxysterol 7 alpha-hydroxylase from pig liver gave results consistent with the contention that the same enzyme is responsible for 7 alpha hydroxylation of both 25-hydroxycholesterol and 27-hydroxycholesterol [5].

Other interactions of CYP39A1

Hepatic CYP39A1 expression is sexually dimorphic (female > male), which is opposite that of CYP7B1 (male > female) [2].

References

Metabolism of 4 beta -hydroxycholesterol in humans. Bodin, K., Andersson, U., Rystedt, E., Ellis, E., Norlin, M., Pikuleva, I., Eggertsen, G., Björkhem, I., Diczfalusy, U. J. Biol. Chem. (2002) [Pubmed]
Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. Li-Hawkins, J., Lund, E.G., Bronson, A.D., Russell, D.W. J. Biol. Chem. (2000) [Pubmed]
Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A). Norlin, M., Andersson, U., Björkhem, I., Wikvall, K. J. Biol. Chem. (2000) [Pubmed]
Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye. Ikeda, H., Ueda, M., Ikeda, M., Kobayashi, H., Honda, Y. Lab. Invest. (2003) [Pubmed]
7 alpha hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7 alpha-hydroxylase. Toll, A., Wikvall, K., Sudjana-Sugiaman, E., Kondo, K.H., Björkhem, I. Eur. J. Biochem. (1994) [Pubmed]

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