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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IP6K2  -  inositol hexakisphosphate kinase 2

Homo sapiens

Synonyms: IHPK2, Inositol hexakisphosphate kinase 2, InsP6 kinase 2, P(i)-uptake stimulator, PIUS, ...
 
 
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Disease relevance of IHPK2

 

High impact information on IHPK2

 

Biological context of IHPK2

  • Overexpression of IHPK2 converts IFN-alpha2-resistant cells into cells that readily undergo apoptosis in response to IFN-alpha2 [1].
  • The IC50 value of IHPK2-expressing cells was 2-3-fold lower than vector control [1].
  • In the present work, PiUS was localized to human chromosome 3p21.3 and is therefore not the ADHR gene [5].
  • A novel gene, PiUS, was recently cloned and shown to increase phosphate uptake when expressed in oocytes, indicating that it may be an important regulator of cellular phosphate homeostasis [5].
 

Anatomical context of IHPK2

 

Associations of IHPK2 with chemical compounds

 

Other interactions of IHPK2

  • Thus overexpression of IHPK2 enhanced apoptotic effects of IFN-beta, and expression of the NLS mutant conferred resistance to IFN-beta [1].
  • Compared with IFN-alpha2, IFN-beta is a more potent inducer of Apo2L/TRAIL and IHPK2 activity [1].
 

Analytical, diagnostic and therapeutic context of IHPK2

References

  1. Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma. Morrison, B.H., Tang, Z., Jacobs, B.S., Bauer, J.A., Lindner, D.J. Biochem. J. (2005) [Pubmed]
  2. Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. Nagata, E., Luo, H.R., Saiardi, A., Bae, B.I., Suzuki, N., Snyder, S.H. J. Biol. Chem. (2005) [Pubmed]
  3. Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells. Morrison, B.H., Bauer, J.A., Kalvakolanu, D.V., Lindner, D.J. J. Biol. Chem. (2001) [Pubmed]
  4. Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. Morrison, B.H., Bauer, J.A., Hu, J., Grane, R.W., Ozdemir, A.M., Chawla-Sarkar, M., Gong, B., Almasan, A., Kalvakolanu, D.V., Lindner, D.J. Oncogene (2002) [Pubmed]
  5. Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3. White, K.E., Econs, M.J. Somat. Cell Mol. Genet. (1998) [Pubmed]
  6. PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase. Schell, M.J., Letcher, A.J., Brearley, C.A., Biber, J., Murer, H., Irvine, R.F. FEBS Lett. (1999) [Pubmed]
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