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Gene Review

ZCCHC17  -  zinc finger, CCHC domain containing 17

Homo sapiens

Synonyms: HSPC243, HSPC251, LDC4, Nucleolar protein of 40 kDa, PS1D, ...
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High impact information on ZCCHC17

  • PS1D is expressed as two isoforms, probably resulting from the alternative splicing of mRNA [1].
  • Immunostaining of endogenous or transfected pNO40 indicated that it is localized to nucleoli of diverse cultured cells, with some concentration in the granular component of nucleoli [2].
  • Several distinct domains are discernable in the ORF of pNO40, including a ribosomal protein S1 RNA binding region, a CCHC type zinc finger, and clusters of basic amino acid representing potential nucleolar targeting signal [2].
  • Characterization of human and mouse pNO40 gene revealed that mouse gene spans 44 kb in length and contains 8 exons, while that of human is 68 kb in length and displays two isoforms generated by alternative splicing of the 5(')-untranslated region and differential usage of translation start site [2].
  • This protein, referred to as pNO40 based on its molecular weight on SDS-PAGE, was identified through yeast two hybrid interaction screen of a human kidney cDNA library using pinin (pnn) protein as the bait [2].

Analytical, diagnostic and therapeutic context of ZCCHC17

  • Analysis of PS1D subcellular distribution by cell fractionation reveals that this protein belongs to the core of the eukaryotic 60S ribosomal subunit [1].
  • Northern blot analysis demonstrated that pNO40 message is expressed ubiquitously across all tissues examined [2].


  1. Identification of ribosomal proteins specific to higher eukaryotic organisms. Gueydan, C., Wauquier, C., De Mees, C., Huez, G., Kruys, V. J. Biol. Chem. (2002) [Pubmed]
  2. Molecular characterization of a novel nucleolar protein, pNO40. Chang, W.L., Lee, D.C., Leu, S., Huang, Y.M., Lu, M.C., Ouyang, P. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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