Gene Review:
PNN - pinin, desmosome associated protein
Homo sapiens
Synonyms:
140 kDa nuclear and cell adhesion-related phosphoprotein, DRS, DRS protein, DRSP, Desmosome-associated protein, ...
- Characterization of the gene encoding pinin/DRS/memA and evidence for its potential tumor suppressor function. Shi, Y., Ouyang, P., Sugrue, S.P. Oncogene (2000)
- memA/DRS, a putative mediator of multiprotein complexes, is overexpressed in the metastasizing human melanoma cell lines BLM and MV3. Degen, W.G., Agterbos, M.A., Muyrers, J.P., Bloemers, H.P., Swart, G.W. Biochim. Biophys. Acta (1999)
- The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus (fogo selvagem). Rock, B., Martins, C.R., Theofilopoulos, A.N., Balderas, R.S., Anhalt, G.J., Labib, R.S., Futamura, S., Rivitti, E.A., Diaz, L.A. N. Engl. J. Med. (1989)
- Phasic events of REM sleep: phenomenology of middle ear muscle activity and periorbital integrated potentials in the same normal population. Benson, K., Zarcone, V.P. Sleep. (1979)
- Cognitive predictors of medication adherence among middle-aged and older outpatients with schizophrenia. Jeste, S.D., Patterson, T.L., Palmer, B.W., Dolder, C.R., Goldman, S., Jeste, D.V. Schizophr. Res. (2003)
- Cognitive functioning in community dwelling older adults with chronic partial epilepsy. Martin, R.C., Griffith, H.R., Faught, E., Gilliam, F., Mackey, M., Vogtle, L. Epilepsia (2005)
- Association between Dementia Rating Scale performance and neurocognitive domains in Alzheimer's disease. Knox, M.R., Lacritz, L.H., Chandler, M.J., Munro Cullum, C. The Clinical neuropsychologist. (2003)
- Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex. Ouyang, P., Sugrue, S.P. J. Cell Biol. (1996)
- Long-term safety of drospirenone-estradiol for hormone therapy: a randomized, double-blind, multicenter trial. Archer, D.F., Thorneycroft, I.H., Foegh, M., Hanes, V., Glant, M.D., Bitterman, P., Kempson, R.L. Menopause (New York, N.Y.) (2005)
- Conception and pharmacodynamic profile of drospirenone. Elger, W., Beier, S., Pollow, K., Garfield, R., Shi, S.Q., Hillisch, A. Steroids (2003)
- Varied acceptance of clinical trial results. Klimt, C.R. Controlled clinical trials. (1989)
- Ethinylestradiol/drospirenone: a review of its use as an oral contraceptive. Keam, S.J., Wagstaff, A.J. Treatments in endocrinology. (2003)
- Yasmin: the reason why. Thorneycroft, I.H. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. (2002)
- Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. Alpatov, R., Munguba, G.C., Caton, P., Joo, J.H., Shi, Y., Shi, Y., Hunt, M.E., Sugrue, S.P. Mol. Cell. Biol. (2004)
- Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus. Shi, J., Sugrue, S.P. J. Biol. Chem. (2000)
- Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization. Berkowitz, P., Hu, P., Liu, Z., Diaz, L.A., Enghild, J.J., Chua, M.P., Rubenstein, D.S. J. Biol. Chem. (2005)
- Modulation of alternative pre-mRNA splicing in vivo by pinin. Wang, P., Lou, P.J., Leu, S., Ouyang, P. Biochem. Biophys. Res. Commun. (2002)
- Reduction of Pnn by RNAi induces loss of cell-cell adhesion between human corneal epithelial cells. Joo, J.H., Alpatov, R., Munguba, G.C., Jackson, M.R., Hunt, M.E., Sugrue, S.P. Mol. Vis. (2005)
- Tyrosine-phosphorylated plakoglobin is associated with desmogleins but not desmoplakin after epidermal growth factor receptor activation. Gaudry, C.A., Palka, H.L., Dusek, R.L., Huen, A.C., Khandekar, M.J., Hudson, L.G., Green, K.J. J. Biol. Chem. (2001)
- Antibodies differentiate desmosome-form and nucleus-form pinin: evidence that pinin is a moonlighting protein with dual location at the desmosome and within the nucleus. Ouyang, P. Biochem. Biophys. Res. Commun. (1999)
- Evidence that "pinin", reportedly a differentiation-specific desmosomal protein, is actually a widespread nuclear protein. Brandner, J.M., Reidenbach, S., Franke, W.W. Differentiation (1997)
- Probabilistic neural network multiple classifier system for predicting the genotoxicity of quinolone and quinoline derivatives. He, L., Jurs, P.C., Kreatsoulas, C., Custer, L.L., Durham, S.K., Pearl, G.M. Chem. Res. Toxicol. (2005)
- Mono-, di-, and tricoordinated phosphorus attached to a N-N unit: an experimental and theoretical study. Fischer, G., Herler, S., Mayer, P., Schulz, A., Villinger, A., Weigand, J.J. Inorganic chemistry. (2005)
- Organoaluminium complexes incorporating an amido phosphine chelate with a pendant amine arm. Lee, W.Y., Liang, L.C. Dalton transactions (Cambridge, England : 2003) (2005)
- Electron-rich, bulky PNN-type ruthenium complexes: synthesis, characterization and catalysis of alcohol dehydrogenation. Zhang, J., Gandelman, M., Shimon, L.J., Milstein, D. Dalton transactions (Cambridge, England : 2003) (2007)
- Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1. Li, C., Lin, R.I., Lai, M.C., Ouyang, P., Tarn, W.Y. Mol. Cell. Biol. (2003)
- Exclusion of Htra2-beta1, an up-regulator of full-length SMN2 transcript, as a modifying gene for spinal muscular atrophy. Helmken, C., Wirth, B. Hum. Genet. (2000)
- Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles. Lin, C.L., Leu, S., Lu, M.C., Ouyang, P. Biochem. Biophys. Res. Commun. (2004)
- Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1. Helmken, C., Hofmann, Y., Schoenen, F., Oprea, G., Raschke, H., Rudnik-Schöneborn, S., Zerres, K., Wirth, B. Hum. Genet. (2003)
- Molecular characterization of a novel nucleolar protein, pNO40. Chang, W.L., Lee, D.C., Leu, S., Huang, Y.M., Lu, M.C., Ouyang, P. Biochem. Biophys. Res. Commun. (2003)