Gene Review:
ABCG5 - ATP-binding cassette, sub-family G (WHITE)...
Bos taurus
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High impact information on ABCG5
- Both ABCG5 and ABCG8 presented a high level of length and sequence identity with other mammalian species [1].
- Identification, sequence analysis and mRNA tissue distribution of the bovine sterol transporters ABCG5 and ABCG8 [1].
- Two members of this family, ABCG5 and ABCG8, are implicated in the intestinal absorption and biliar excretion of sterols [1].
- As expected, high expression levels of both ABCG5 and ABCG8 were present in liver and digestive tract samples, and interestingly, in the mammary gland, opening new avenues for further investigation about their potential role in lipid trafficking and excretion during lactation [1].
Analytical, diagnostic and therapeutic context of ABCG5
- In the present work, expression of ABCG5 and ABCG8 in the bovine was demonstrated for the first time and characterized by quantitative PCR [1].
References
- Identification, sequence analysis and mRNA tissue distribution of the bovine sterol transporters ABCG5 and ABCG8. Viturro, E., Farke, C., Meyer, H.H., Albrecht, C. J. Dairy Sci. (2006) [Pubmed]
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