The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Abcg5  -  ATP-binding cassette, sub-family G (WHITE)...

Mus musculus

Synonyms: ATP-binding cassette sub-family G member 5, AW112016, Sterolin-1, cmp, sterolin-1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Abcg5


High impact information on Abcg5

  • Hepatic expression of Abcg8 was reduced by about 35% in Abcg5-deficient mice when compared with controls [2].
  • Surprisingly, high plasma beta-sitosterol and campesterol concentrations were even further elevated in Abcg5-null mice on treatment with the synthetic LXR agonist T0901317 (0.015% dietary supplementation, 10 days), whereas these concentrations were reduced by approximately 75% in wild-type mice [2].
  • CONCLUSIONS: Our data show that disruption of the Abcg5 gene alone is sufficient to cause hyperabsorption of dietary plant sterols and sitosterolemia in mice, whereas the ability to secrete cholesterol into bile is maintained [2].
  • METHODS: To test whether deficiency of ABCG5 alone is sufficient to induce sitosterolemia, Abcg5-null mice were generated and characterized with respect to sterol metabolism [2].
  • RESULTS: Abcg5 deficiency was associated with strongly elevated plasma levels of beta-sitosterol (37-fold) and campesterol (7.7-fold) as well as reduced plasma cholesterol concentrations (-40%) [2].

Biological context of Abcg5

  • A significant locus associated with gallstone score on chromosome 17, named Lith9 (susceptibility allele conferred by strain PERA/Ei), colocalizes with the genes Abcg5 and Abcg8 that encode the canalicular cholesterol transporter [3].
  • Expression of Abcg5 and Abcg8, recently implicated in biliary excretion of cholesterol and its intestinal absorption, was induced in T0901317-treated mice [4].
  • Analysis of the kinetics of cholesterol secretion suggested that diosgenin probably activates a step before Abcg5/g8 [5].
  • Haplotype analysis narrowed this QTL, and sequencing of the candidate genes Abcg5 and Abcg8 confirmed shared alleles in strains I/LnJ and DBA/2J that differed from the alleles in strain PERA/EiJ [6].
  • Plant sterol and stanol-induced reduction of cholesterol absorption in mice is not associated with upregulation of intestinal LXR target genes nor is it influenced by Abcg5-deficiency [7].

Anatomical context of Abcg5


Associations of Abcg5 with chemical compounds

  • Despite similar bile salt (BS) excretion rates, basal total sterol and phospholipid (PL) output rates were reduced by 82% and 35%, respectively, in chow-fed Abcg5(-/-) mice compared with wild-type mice [1].
  • When mice were infused with the hydrophilic BS tauroursodeoxycholate, similar relative increases in bile flow, BS output, PL output, and total sterol output were observed in wild-type, Abcg5(+/-), and Abcg5(-/-) mice [1].
  • The plant sterol diosgenin has been shown to stimulate biliary cholesterol secretion in mice without affecting the expression of the adenosine triphosphate-binding cassette transporter heterodimer Abcg5/g8 [5].
  • Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8 [10].

Physical interactions of Abcg5


Other interactions of Abcg5

  • To elucidate the roles of ABCG5 and ABCG8 in the trafficking of sterols, we disrupted Abcg5 and Abcg8 in mice (G5G8(-/-)) [11].


  1. Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice. Plösch, T., van der Veen, J.N., Havinga, R., Huijkman, N.C., Bloks, V.W., Kuipers, F. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  2. Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor. Plösch, T., Bloks, V.W., Terasawa, Y., Berdy, S., Siegler, K., Van Der Sluijs, F., Kema, I.P., Groen, A.K., Shan, B., Kuipers, F., Schwarz, M., Schwartz, M. Gastroenterology (2004) [Pubmed]
  3. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Wittenburg, H., Lyons, M.A., Li, R., Churchill, G.A., Carey, M.C., Paigen, B. Gastroenterology (2003) [Pubmed]
  4. Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. Plōsch, T., Kok, T., Bloks, V.W., Smit, M.J., Havinga, R., Chimini, G., Groen, A.K., Kuipers, F. J. Biol. Chem. (2002) [Pubmed]
  5. Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8. Kosters, A., Frijters, R.J., Kunne, C., Vink, E., Schneiders, M.S., Schaap, F.G., Nibbering, C.P., Patel, S.B., Groen, A.K. Hepatology (2005) [Pubmed]
  6. QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains. Wittenburg, H., Lyons, M.A., Li, R., Kurtz, U., Wang, X., Mössner, J., Churchill, G.A., Carey, M.C., Paigen, B. J. Lipid Res. (2006) [Pubmed]
  7. Reduction of cholesterol absorption by dietary plant sterols and stanols in mice is independent of the Abcg5/8 transporter. Plösch, T., Kruit, J.K., Bloks, V.W., Huijkman, N.C., Havinga, R., Duchateau, G.S., Lin, Y., Kuipers, F. J. Nutr. (2006) [Pubmed]
  8. Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice. Kosters, A., Frijters, R.J., Schaap, F.G., Vink, E., Plösch, T., Ottenhoff, R., Jirsa, M., De Cuyper, I.M., Kuipers, F., Groen, A.K. J. Hepatol. (2003) [Pubmed]
  9. Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice. Duan, L.P., Wang, H.H., Wang, D.Q. J. Lipid Res. (2004) [Pubmed]
  10. Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8. Lu, K., Lee, M.H., Yu, H., Zhou, Y., Sandell, S.A., Salen, G., Patel, S.B. J. Lipid Res. (2002) [Pubmed]
  11. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Yu, L., Hammer, R.E., Li-Hawkins, J., Von Bergmann, K., Lutjohann, D., Cohen, J.C., Hobbs, H.H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
WikiGenes - Universities