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Gene Review:

OAZ3 - ornithine decarboxylase antizyme 3

Homo sapiens

Synonyms: AZ3, OAZ-t, ODC-Az 3, Ornithine decarboxylase antizyme 3, TISP15

Christensen, G.L. et al., Fitzgerald, C. et al., Saul, D.J. et al.

Christensen, Ivanov, Wooding, Atkins, Mielnik, Schlegel, Carrell,

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Disease relevance of OAZ3

CONCLUSION: Mutations in the OAZ3 gene are not a common cause of male infertility [1].

High impact information on OAZ3

Cytoplasmic Oaz3 mRNA is completely testis specific [2].
In the study of rat sperm tail proteins a cDNA, called 1038, was isolated representing a hybrid mRNA derived in part from the ornithine decarboxylase antizyme 3 (Oaz3) gene located on rat chromosome 2 fused to sequences encoded by a novel gene on chromosome 4 [2].
RESULTS: A total of 23 polymorphisms were identified in the promoter, exons or intronic regions of OAZ3 [1].
This trait may be related to another function of OAZ3 or a region in tight linkage disequilibrium to the gene [1].
Identified polymorphisms in the OAZ3 gene were further subjected to a haplotype analysis using PHASE 2.02 and Arlequin 2.0 software programs [1].

Biological context of OAZ3

The coding sequence of OAZ3 was further screened for polymorphisms by SSCP analysis in the infertile group and an additional 250 general population controls [1].
Ornithine decarboxylase antizyme 3 (OAZ3) is a testis-specific antizyme paralog and the only antizyme expressed in the mid to late stages of spermatogenesis [1].
The SSU rRNA gene of the extremely thermophilic bacterium strain AZ3 B.1, encodes an rRNA containing four large inserts [3].

References

Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3. Christensen, G.L., Ivanov, I.P., Wooding, S.P., Atkins, J.F., Mielnik, A., Schlegel, P.N., Carrell, D.T. BMC Med. Genet. (2006) [Pubmed]
Mammalian transcription in support of hybrid mRNA and protein synthesis in testis and lung. Fitzgerald, C., Sikora, C., Lawson, V., Dong, K., Cheng, M., Oko, R., van der Hoorn, F.A. J. Biol. Chem. (2006) [Pubmed]
Secondary structure model for an unusual SSU rRNA from the extremely thermophilic bacterium strain AZ3 B.1. Saul, D.J., Williams, L.C., Reeves, R.A., Bergquist, P.L. Biochim. Biophys. Acta (1994) [Pubmed]

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