Disease relevance of PEPE

• The contribution by Pepe and colleagues provides additional evidence that initial defibrillation is not necessarily the optimal intervention for victims of cardiac arrest and especially when cardiac arrest has been untreated for more than 3 min [1].

High impact information on PEPE

• Recently, the dermal fibroblasts (ATCC CRL 1262) of a lethal perinatal variant of osteogenesis imperfecta have been used for the first molecular characterization of a collagen gene defect (Chu, M. L., Williams, C. J., Pepe, G., Hirsch, J. L., Prockop, D. J., and Ramirez, F. (1983) Nature (Lond.) 304, 78-80) [2].
• Assignment of the human aminopeptidase N (peptidase E) gene to chromosome 15q13-qter [3].
• The distributions of the immunoreactive labeling for LENK, MENK, MERF, BAM22P, and PEPE were indistinguishable, and double-label studies showed that LENK, MERF, and BAM22P were colocalized within individual neurons and fibers [4].
• Antisera against several enkephalin peptides were used: leucine-enkephalin (LENK), methionine-enkephalin (MENK), methionine-enkephalin-arg6-phe7 (MERF), methionine-enkephalin-arg6-gly7-leu8 (MERGL), Peptide E (PEPE), and BAM22P [4].
• Evidence is presented indicating that the human gene for Peptidase E is on chromosome 17 in the region 17q23----17qter [5].

Anatomical context of PEPE

• The results indicated that LENK, MENK, and MERF (or highly similar peptides) are present in the turtle central nervous system, and that a peptide showing immunological similarity to BAM22P and PEPE also appeared to be present [4].

Associations of PEPE with chemical compounds

• Lan, Simon, and Halperin (1982, Communications in Statistics C1, 207-219) calculate this probability under the design alternative, and Pepe and Anderson (1992, Applied Statistics 41, 181-190) use an alternative based solely on the current data [6].

References