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Gene Review:

STX18 - syntaxin 18

Homo sapiens

Synonyms: Cell growth-inhibiting gene 9 protein, GIG9, Syntaxin-18, Ufe1

Hatsuzawa, K. et al., Hatsuzawa, K. et al., Bossis, I. et al.

Hatsuzawa, Tamura, Hashimoto, Hashimoto, Yokoya, Miura, Nagaya, Wada,

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Disease relevance of STX18

Interaction of tSNARE syntaxin 18 with the papillomavirus minor capsid protein mediates infection [1].

High impact information on STX18

Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE protein, in ER-mediated phagocytosis [2].
Therefore, we conclude that syntaxin 18 is involved in ER-mediated phagocytosis, presumably by regulating the specific and direct fusion of the ER and plasma or phagosomal membranes [2].
Fluorescence and immuno-EM analyses confirmed the localization of syntaxin 18 in the phagosomal membranes of J774 cells stably expressing this protein tagged to a GFP variant [2].
When phagosomes were isolated from murine J774 macrophages, we found that ER-localized SNARE proteins (syntaxin 18, D12, and Sec22b) were significantly enriched in the phagosomes [2].
By using the yeast two-hybrid system, we have identified a novel member of the syntaxin family, syntaxin 18, that binds to alpha-soluble N-ethylmaleimide-sensitive factor-attachment protein [3].

Biological context of STX18

We examined the effect of overexpression of FLAG-tagged syntaxin 18 and a mutant lacking the N-terminal 81 amino acid residues on protein transport and organelles in the early secretory pathway [3].
Expression in these cells of dominant-negative mutants of syntaxin 18 or D12 lacking the transmembrane domain, but not a Sec22b mutant, impaired phagocytosis [2].

Anatomical context of STX18

These results taken together suggest that syntaxin 18 functions in transport between the endoplasmic reticulum and Golgi [3].
Both expressed proteins localized to the endoplasmic reticulum, and the expressed FLAG-syntaxin 18 caused remarkable aggregation of endoplasmic reticulum membranes [3].

Other interactions of STX18

Although expression of the FLAG-syntaxin 18 lacking the N-terminal region produced less effect on the morphology of the endoplasmic reticulum, dispersion of the endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi was elicited [3].

References

Interaction of tSNARE syntaxin 18 with the papillomavirus minor capsid protein mediates infection. Bossis, I., Roden, R.B., Gambhira, R., Yang, R., Tagaya, M., Howley, P.M., Meneses, P.I. J. Virol. (2005) [Pubmed]
Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE protein, in ER-mediated phagocytosis. Hatsuzawa, K., Tamura, T., Hashimoto, H., Hashimoto, H., Yokoya, S., Miura, M., Nagaya, H., Wada, I. Mol. Biol. Cell (2006) [Pubmed]
Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking. Hatsuzawa, K., Hirose, H., Tani, K., Yamamoto, A., Scheller, R.H., Tagaya, M. J. Biol. Chem. (2000) [Pubmed]

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