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Gene Review:

PPIL3 - peptidylprolyl isomerase (cyclophilin)-like 3

Homo sapiens

Synonyms: CyPJ, Cyclophilin J, Cyclophilin-like protein PPIL3, PPIase, Peptidyl-prolyl cis-trans isomerase-like 3, ...

Zhou, Z. et al., Huang, L.L. et al., Qi, Z.Y. et al., Hu, H. et al.

Qi, Hui, Li, Zhou, Gu, Ying, Xie,

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Disease relevance of PPIL3

The novel full-length gene of human PPIL3 may be correlated with the formation of human glioma [1].
Recombinant hCyPJ was expressed in Escherichia coli and purified [2].

High impact information on PPIL3

His43 and Gln52 of hCyPJ are expected to be the active sites based on sequence alignment with hCyPA [2].
The PPIL3 gene consisted of eight exons spanning more than 18 kb of genomic DNA [3].
The PPIL3 gene was identified on a completely sequenced BAC (GenBank accession AC005037) from chromosome 2q33 between STS markers stSG2762 (proximal) and SHGC-3074 (distal), oriented toward the telomere [3].

Analytical, diagnostic and therapeutic context of PPIL3

RT-PCR analysis indicated that PPIL3 was ubiquitously expressed in adult human tissues [3].
Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain [3].
Crystallization and preliminary X-ray crystallographic studies of human cyclophilin J [4].

References

cDNA microarray in isolation of novel differentially expressed genes related to human glioma and clone of a novel full-length gene. Qi, Z.Y., Hui, G.Z., Li, Y., Zhou, Z.X., Gu, S.H., Ying, K., Xie, Y. Chin. Med. J. (2005) [Pubmed]
Structure of recombinant human cyclophilin J, a novel member of the cyclophilin family. Huang, L.L., Zhao, X.M., Huang, C.Q., Yu, L., Xia, Z.X. Acta Crystallogr. D Biol. Crystallogr. (2005) [Pubmed]
Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain. Zhou, Z., Ying, K., Dai, J., Tang, R., Wang, W., Huang, Y., Zhao, W., Xie, Y., Mao, Y. Cytogenet. Cell Genet. (2001) [Pubmed]
Crystallization and preliminary X-ray crystallographic studies of human cyclophilin J. Hu, H., Huang, C.Q., Liu, H.L., Han, Y., Yu, L., Bi, R.C. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2005) [Pubmed]

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AgaP_AGAP009996	Anopheles gambiae str. PEST
AT1G01940	Arabidopsis thaliana
PPIL3	Bos taurus
cyn-10	Caenorhabditis elegans
PPIL3	Canis lupus familiaris
zgc:86715	Danio rerio
CG11777	Drosophila melanogaster
PPIL3	Gallus gallus
PPIL3	Macaca mulatta
MGG_03239	Magnaporthe oryzae 70-15
Ppil3	Mus musculus
NCU10388	Neurospora crassa OR74A
Os06g0130500	Oryza sativa Japonica Group
PPIL3	Pan troglodytes
Ppil3	Rattus norvegicus
ppil3	Xenopus (Silurana) tropicalis

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