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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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CPSF2  -  cleavage and polyadenylation specific...

Homo sapiens

Synonyms: CPSF 100 kDa subunit, CPSF100, Cleavage and polyadenylation specificity factor 100 kDa subunit, Cleavage and polyadenylation specificity factor subunit 2, KIAA1367
 
 
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High impact information on CPSF2

  • CstF 64 kDa and CPSF 100 kDa were distributed in a fibrogranular pattern in the nucleoplasm and, in addition, were concentrated in 1-4 bright foci [1].
  • A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100 [2].
  • CPSF-73 contains a zinc-binding histidine motif involved in catalysis in other members of the beta-lactamase superfamily, whereas CPSF-100 has substitutions within the histidine motif and thus is unlikely to be catalytically active [2].
 

Biological context of CPSF2

  • Formation of the mature 3' ends of the vast majority of cellular mRNAs occurs through cleavage and polyadenylation and requires a cleavage and polyadenylation specificity factor (CPSF) containing, among other proteins, CPSF-73 and CPSF-100 [2].
  • Here, we report that whereas DDX1 bodies, CBs and gems are present throughout interphase, CPSF-100-containing cleavage bodies are predominantly found during S and G2 phases, whereas CstF-64-containing cleavage bodies are primarily observed during S phase [3].
 

Anatomical context of CPSF2

  • The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA [1].

References

  1. The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA. Schul, W., Groenhout, B., Koberna, K., Takagaki, Y., Jenny, A., Manders, E.M., Raska, I., van Driel, R., de Jong, L. EMBO J. (1996) [Pubmed]
  2. A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100. Dominski, Z., Yang, X.C., Purdy, M., Wagner, E.J., Marzluff, W.F. Mol. Cell. Biol. (2005) [Pubmed]
  3. Dynamic nature of cleavage bodies and their spatial relationship to DDX1 bodies, Cajal bodies, and gems. Li, L., Roy, K., Katyal, S., Sun, X., Bléoo, S., Godbout, R. Mol. Biol. Cell (2006) [Pubmed]
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