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Gene Review

DCUN1D1  -  DCN1, defective in cullin neddylation 1,...

Homo sapiens

Synonyms: DCN1-like protein 1, DCNL1, DCUN1 domain-containing protein 1, DCUN1L1, Defective in cullin neddylation protein 1-like protein 1, ...
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Disease relevance of DCUN1D1


High impact information on DCUN1D1

  • We identified and characterized a novel oncogene, SCC-related oncogene (SCCRO), which is amplified along the 3q26.3 region in human SCC [1].
  • The importance of SCCRO amplification in malignant transformation is established by the apoptotic response to short hairpin RNA against SCCRO, exclusively in cancer cell lines carrying SCCRO amplification [1].
  • The oncogenic potential of SCCRO is underscored by its ability to transform fibroblasts (NIH-3T3 cells) in vitro and in vivo [1].
  • Collectively, these data suggest that SCCRO is a novel component of the HH signaling pathway involved in the malignant transformation of squamous cell lineage [1].
  • Univariate analyses demonstrated that SCCRO overexpression correlated with nodal metastases (P = 0.05) and advanced stage (P = 0.02), whereas PIK3CA overexpression was associated with vascular invasion (P = 0.04) [2].

Biological context of DCUN1D1


Anatomical context of DCUN1D1

  • RESULTS: SCCRO expression was detected in the murine adrenal cortex as early as E15 and persisted into the postnatal period [3].

Other interactions of DCUN1D1


Analytical, diagnostic and therapeutic context of DCUN1D1


  1. Squamous Cell Carcinoma Related Oncogene/DCUN1D1 Is Highly Conserved and Activated by Amplification in Squamous Cell Carcinomas. Sarkaria, I., O-Charoenrat, P., Talbot, S.G., Reddy, P.G., Ngai, I., Maghami, E., Patel, K.N., Lee, B., Yonekawa, Y., Dudas, M., Kaufman, A., Ryan, R., Ghossein, R., Rao, P.H., Stoffel, A., Ramanathan, Y., Singh, B. Cancer Res. (2006) [Pubmed]
  2. The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue. Estilo, C.L., O-Charoenrat, P., Ngai, I., Patel, S.G., Reddy, P.G., Dao, S., Shaha, A.R., Kraus, D.H., Boyle, J.O., Wong, R.J., Pfister, D.G., Huryn, J.M., Zlotolow, I.M., Shah, J.P., Singh, B. Clin. Cancer Res. (2003) [Pubmed]
  3. Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas. Sarkaria, I.S., Stojadinovic, A., Talbot, S.G., Hoos, A., Dudas, M.E., Brennan, M.F., Ghossein, R.A., Singh, B. Surgery (2004) [Pubmed]
  4. SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma. Sarkaria, I.S., Pham, D., Ghossein, R.A., Talbot, S.G., Hezel, M., Dudas, M.E., Ebright, M.I., Chuai, S., Memoli, N., Venkatraman, E.S., Miller, V.A., Kris, M.G., Zakowski, M.F., Rusch, V.W., Singh, B. Ann. Thorac. Surg. (2004) [Pubmed]
  5. Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A. Talbot, S.G., O-charoenrat, P., Sarkaria, I.S., Ghossein, R., Reddy, P., Ngai, I., Cordeiro, C.N., Wong, R.J., Kris, M.G., Rusch, V.W., Singh, B. Ann. Surg. Oncol. (2004) [Pubmed]
  6. Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16. Mas, C., Bourgeois, F., Bulfone, A., Levacher, B., Mugnier, C., Simonneau, M. Genomics (2000) [Pubmed]
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