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Gene Review

Cd5  -  Cd5 molecule

Rattus norvegicus

Synonyms: T-cell surface glycoprotein CD5
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High impact information on Cd5

  • Most IEL bearing CD8 expressed no CD5 antigen in young rats, while all CD4+CD8+ IEL and some of CD8+ IEL in aged rats were of CD5+CD45RB- phenotype [1].
  • A requirement for the CD5 antigen in T cell activation [2].
  • Fostering also down-regulated CD5 antigen expression in E compared with C offspring and up-regulated CD4 antigen expression in C offspring compared with their nonfostered counterparts [3].
  • In this way, the pool of Lyt 1 T lymphocytes capable of attracting and activating macrophages at the site of bacterial and implantation via lymphokines (macrophage activating factor, migration inhibition factor) could be markedly enhanced [4].
  • Most probably, H2-restricted interactions between antigen-presenting mononuclear phagocytes and Lyt 1 T lymphocytes induce secretion of interleukins which further recruit additional Lyt 1 T lymphocytes from the Lyt 123 T lymphocyte set [4].

Other interactions of Cd5

  • However, after fostering, E females had higher CD45RA and CD5 antigen expression compared with PF and C females, whereas E males had increased CD4 antigen expression and C males had decreased CD5 antigen expression compared with their nonfostered counterparts [3].


  1. Age-associated increase in number of CD4+CD8+ intestinal intraepithelial lymphocytes in rats. Takimoto, H., Nakamura, T., Takeuchi, M., Sumi, Y., Tanaka, T., Nomoto, K., Yoshikai, Y. Eur. J. Immunol. (1992) [Pubmed]
  2. A requirement for the CD5 antigen in T cell activation. McAteer, M.J., Lagarde, A.C., Georgiou, H.M., Bellgrau, D. Eur. J. Immunol. (1988) [Pubmed]
  3. Effect of surrogate fostering on splenic lymphocytes in fetal ethanol exposed rats. Giberson, P.K., Weinberg, J. Alcohol. Clin. Exp. Res. (1997) [Pubmed]
  4. T lymphocyte-macrophage interactions in cellular antibacterial immunity. Hahn, H., Kaufmann, S.H. Immunobiology (1982) [Pubmed]
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