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Gene Review

Cd5  -  CD5 antigen

Mus musculus

Synonyms: Ly-1, Ly-12, Ly-A, Lymphocyte antigen 1, Lyt-1, ...
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Disease relevance of Cd5


Psychiatry related information on Cd5

  • In applying the long term culture method, we have established a cloned B cell line named B19-1d, B19-1d cells are specific to MOPC104E or J558 cross-reactive Id and they express surface mu, lambda but no Ly-1 [6].

High impact information on Cd5

  • We found that the CFU-T contains both a Thy-1+ and a Thy-1- cell, neither of which seems to carry either Lyt-1 or Lyt-2 surface markers [7].
  • A cDNA encoding a novel zinc finger protein has been isolated from a mouse T-cell leukemia line on the basis of its expression of a Ly-1 epitope in a lambda gt11 library [8].
  • In contrast, self-antigen-induced clonal deletion of mature self-reactive Ly-1 B (B1) cells in the peritoneal cavity was inhibited in the transgenic mice [9].
  • These data suggest that the enrichment of ATA B cells in the Ly-1 B subset is primarily due to repeated independent recruitment of B cells by antigen resulting in the expression of a restricted set of VH genes [10].
  • VH region gene sequence data of 14 monoclonal ATA from Ly-1 B cell-derived hybridomas reveal the utilization of nine VH genes belonging to four different VH families (J558, 3609, Q52, and Vgam3.8) [10].

Biological context of Cd5

  • The predicted secondary structure of the first amino-terminal subregion and identities of certain conserved residues among most members of the immunoglobulin gene superfamily suggest that Ly-1 and Leu-1 are distant members of this family [11].
  • Analysis of the predicted amino acid sequence indicated that the Ly-1 polypeptide is synthesized with a 23 amino acid leader and that the mature protein consists of an amino-terminal region of 347 amino acids, a transmembrane sequence of 30 residues, and a carboxyl-terminal region of 94 amino acids [11].
  • They do not express the T cell-lineage antigens Thy-1, Lyt-1, or Lyt-2 (only 1 to 3% positive) [12].
  • Along with previously mapped genes including Ly-1 and CD20, OSBP defines a new conserved syntenic group on the long arm of chromosome 11 in the human and the proximal end of chromosome 19 in the mouse [13].
  • Human OKT4 and OKM1 phenotypes were transiently expressed by one clone and mouse Lyt 1 by two other clones [14].

Anatomical context of Cd5

  • Thus, even among splenic and lymph node T cells subpopulations exist that tend to be either high Thy-1 and low Lyt-1 or vice versa [15].
  • The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice [16].
  • We detect at least some Lyt-1 on all T (Thy-1-bearing) lymphocytes; however, in agreement with previous studies, we find that Lyt-2+3+ cells are more difficult to depelete with anti-Lyt-1 than Lyt-1+2-3- cells [15].
  • Among Lyt-1+2+3+ cells in the thymus, Thy-1 and Lyt-2 are high, whereas Lyt-1 is low [15].
  • Studies with FACS-sorted cells show that the presence of Ly-1 on these IgM-secreting cells distinguishes them from the (Ly-1 negative) IgM-secreting "direct" plaque-forming cells generated in NZB mice after stimulation with sheep erythrocytes [16].

Associations of Cd5 with chemical compounds

  • However, Lyt-1, Lyt-2, surface Ig, IE, MAC-1, and Fc and C3 receptor markers were not detected [17].
  • Molecular cloning of Ly-1, a membrane glycoprotein of mouse T lymphocytes and a subset of B cells: molecular homology to its human counterpart Leu-1/T1 (CD5) [11].
  • The entire amino-terminal region is rich in cysteine, with all of its 22 cysteine residues conserved between Ly-1 and Leu-1 [11].
  • The amino-terminal region appears to be divided into two subregions by a threonine- and proline-rich sequence of 23 amino acids that is highly conserved between Ly-1 and its human homologue Leu-1 (CD5) in position and amino acid composition [11].
  • This NK activity was further shown to be associated with a subpopulation of cells bearing surface Thy-1, Ly-5, and NK-1 as well as asialo-GM1 antigens but lacking Ly-1 antigen [18].

Physical interactions of Cd5

  • Lyb-2/CD72 is a 45-kDa mouse B cell surface protein that binds CD5 (Ly-1) and has been shown to induce B cell proliferation upon mAb binding [19].
  • This factor is composed of at least two subunits which come from cells expressing different Ly phenotypes; an antigen-specific antigen-binding "subfactor" is made by an Ly-1 cell and a non-antigen-binding one is made by an Ly-2 cell [20].

Regulatory relationships of Cd5


Other interactions of Cd5

  • Although Thy-1+ they were negative for other differentiation antigens including Ly-1, Ly-2 and L3T4 [23].
  • The Lyt-2+3+ cells are found predominantly in the low Lyt-1, high Thy-1 subpopulation [15].
  • Under normal circumstances the Ly-1 TsiF activity is restricted by Igh-V-linked genetic polymorphisms [24].
  • To test in vivo whether DNTs persist abnormally or have a capacity to differentiate into single-positive T cells, we have performed cell transfer experiments between congenic strains of lpr and +/+ mice differentially marked by expression of the Ly-1 or Thy-1 alleles [25].
  • The gene order Ly-1 - Got-1 - 4.7 +/- 1.6 - Es-18 is suggested [26].

Analytical, diagnostic and therapeutic context of Cd5


  1. Alloantigenic phenotype of radiation-induced thymomas in the mouse. Hogarth, P.M., Henning, M.M., McKenzie, I.F. J. Natl. Cancer Inst. (1982) [Pubmed]
  2. Quantitative immunofluorescent analysis of surface phenotypes of murine B cell lymphomas and plasmacytomas with monoclonal antibodies. Lanier, L.L., Warner, N.L., Ledbetter, J.A., Herzenberg, L.A. J. Immunol. (1981) [Pubmed]
  3. Experimental systemic amyloidosis induced by immunization with syngeneic organ extracts in mice. Mori, Y., Akikusa, B., Mori, T., Ueda, S., Iesato, K., Yoshida, H., Ogawa, M., Kato, I., Wakashin, Y., Wakashin, M. J. Exp. Med. (1986) [Pubmed]
  4. Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. I. Requirement of Lyt-1 dull L3T4 bright normal T cells for the induction of thyroiditis. Sugihara, S., Izumi, Y., Yoshioka, T., Yagi, H., Tsujimura, T., Tarutani, O., Kohno, Y., Murakami, S., Hamaoka, T., Fujiwara, H. J. Immunol. (1988) [Pubmed]
  5. Aberrant expression of Forssman and Paul-Bunnell antigens on lymph node cells of MRL/Mp-lpr/lpr mice. Katagiri, T., Mori, T., Nakano, T., Ueno, K., Kano, K. J. Immunol. (1984) [Pubmed]
  6. Evidence for idiotypic- and antiidiotypic B-B cellular interaction with the use of cloned antiidiotypic B cell line. Bitoh, S., Fujimoto, S., Yamamoto, H. J. Immunol. (1990) [Pubmed]
  7. Generation of cytotoxic T-lymphocyte precursor cells in T-cell colonies grown in vitro. Ching, L.M., Miller, R.G. Nature (1981) [Pubmed]
  8. LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation. Su, L., Hershberger, R.J., Weissman, I.L. Genes Dev. (1993) [Pubmed]
  9. The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow. Nisitani, S., Tsubata, T., Murakami, M., Okamoto, M., Honjo, T. J. Exp. Med. (1993) [Pubmed]
  10. Natural autoantibodies to thymocytes: origin, VH genes, fine specificities, and the role of Thy-1 glycoprotein. Hayakawa, K., Carmack, C.E., Hyman, R., Hardy, R.R. J. Exp. Med. (1990) [Pubmed]
  11. Molecular cloning of Ly-1, a membrane glycoprotein of mouse T lymphocytes and a subset of B cells: molecular homology to its human counterpart Leu-1/T1 (CD5). Huang, H.J., Jones, N.H., Strominger, J.L., Herzenberg, L.A. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  12. Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. Butcher, E.C., Rouse, R.V., Coffman, R.L., Nottenburg, C.N., Hardy, R.R., Weissman, I.L. J. Immunol. (1982) [Pubmed]
  13. cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19. Levanon, D., Hsieh, C.L., Francke, U., Dawson, P.A., Ridgway, N.D., Brown, M.S., Goldstein, J.L. Genomics (1990) [Pubmed]
  14. Characterization of a human X mouse T cell hybridoma and identification of a clone secreting and binding interleukin-2. Durrant, L.G., Parkar, M., Kenworthy, N., Taylor, G.M. Immunology (1984) [Pubmed]
  15. T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. Ledbetter, J.A., Rouse, R.V., Micklem, H.S., Herzenberg, L.A. J. Exp. Med. (1980) [Pubmed]
  16. The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice. Hayakawa, K., Hardy, R.R., Parks, D.R., Herzenberg, L.A. J. Exp. Med. (1983) [Pubmed]
  17. Cloned natural suppressor cell lines derived from the spleens of neonatal mice. Schwadron, R.B., Gandour, D.M., Strober, S. J. Exp. Med. (1985) [Pubmed]
  18. Generation of natural killer cell lines from murine long-term bone marrow cultures. Yung, Y.P., Okumura, K., Moore, M.A. J. Immunol. (1985) [Pubmed]
  19. Biochemical identity of the mouse Ly-19.2 and Ly-32.2 alloantigens with the B cell differentiation antigen Lyb-2/CD72. Robinson, W.H., Landolfi, M.M., Schäfer, H., Parnes, J.R. J. Immunol. (1993) [Pubmed]
  20. Interactions between molecules (subfactors) released by different T cell sets that yield a complete factor with biological (suppressive) activity. Ptak, W., Rosenstein, R.W., Gershon, R.K. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  21. FcgammaRIa-gamma-chain complexes trigger antibody-dependent cell-mediated cytotoxicity (ADCC) in CD5+ B cell/macrophage IIA1.6 cells. Van Vugt, M.J., Van den Herik-Oudijk, I.E., Van de Winkel, J.G. Clin. Exp. Immunol. (1998) [Pubmed]
  22. Identification of a unique lymphocyte subpopulation in the sheep uterus. Lee, C.S., Gogolin-Ewens, K., Brandon, M.R. Immunology (1988) [Pubmed]
  23. In vitro properties of murine autoreactive T cell clones with specificity for erythrocytes. Gibson, J., Basten, A. Autoimmunity (1988) [Pubmed]
  24. Homologies between cell interaction molecules controlled by major histocompatibility complex- and Igh-V-linked genes that T cells use for communication; both molecules undergo "adaptive" differentiation in the thymus. Yamauchi, K., Flood, P.M., Singer, A., Gershon, R.K. Eur. J. Immunol. (1983) [Pubmed]
  25. The abnormal lpr double-negative T cell fails to proliferate in vivo. Sobel, E.S., Kakkanaiah, V.N., Rapoport, R.G., Eisenberg, R.A., Cohen, P.L. Clin. Immunol. Immunopathol. (1995) [Pubmed]
  26. Esterase-18 (ES-18) of the house mouse (Mus musculus): biochemical characterization and genetics of an allozyme system linked to chromosome 19. von Deimling, O.H., Gaa, A., Simon, M.M. Biochem. Genet. (1988) [Pubmed]
  27. Age-associated increase in expression of the T cell surface markers Thy-1, Lyt-1, and Lyt-2 in congenitally athymic (nu/nu) mice: analysis by flow microfluorometry. MacDonald, H.R., Lees, R.K., Sordat, B., Zaech, P., Maryanski, J.L., Bron, C. J. Immunol. (1981) [Pubmed]
  28. Immunologic alterations in MRL/lpr mice after chronic dimethyl sulfoxide administration. Wysenbeek, A.J., Lourie, S., Weinberger, A., Schoenfeld, N., Pick, A.I., Pecht, M. Int. J. Immunopharmacol. (1987) [Pubmed]
  29. Effects of Lyt antibodies on T-cell functions: augmentation by anti-Lyt-1 as opposed to inhibition by anti-Lyt-2. Hollander, N., Pillemer, E., Weissman, I.L. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  30. LGL-1: a non-polymorphic antigen expressed on a major population of mouse natural killer cells. Mason, L., Giardina, S.L., Hecht, T., Ortaldo, J., Mathieson, B.J. J. Immunol. (1988) [Pubmed]
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