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Gene Review

CD5  -  CD5 molecule

Bos taurus

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Disease relevance of CD5


High impact information on CD5

  • Though peripheral blood B cells from healthy sheep were known to be devoid of the CD5 T cell marker, it appears from our study that most B cells from bovine leukemia virus- (BLV) infected sheep with hematological disorders express both the CD5 marker and surface IgM [1].
  • In contrast, anti-CD5 mAb did not increase proliferation in the AMLR even though both CD5 and WC1 are members of the scavenger receptor cysteine-rich family of proteins and are expressed by bovine peripheral blood gamma/delta T cells [2].
  • The results indicate that BLT-1 recognizes an epitope of the bovine homologue of CD5 and that perturbation of the epitope by MAb binding results in signal transduction to bovine lymphocytes [3].
  • Biochemical studies included the CD2 and CD5 molecules and further demonstrated their similarity to equivalent molecules in other species, confirming the phylogenetic importance of these molecules in immune responses [4].
  • Cells expressing GM-CSF receptor were Ig positive and both CD5 and CD11 positive (B-1a cell) [5].

Biological context of CD5


Anatomical context of CD5

  • In competitive assays for lymphocyte surface binding, BLT-1 and MAb CC-29 (which had been shown previously to react with bovine CD5) blocked one another, indicating that the epitopes recognized were identical or extensively overlapping [3].
  • All cell lines expressed CD2, CD5 and CD25 [8].
  • Frozen sections of the tissues were immunohistochemically stained using monoclonal antibodies against surface markers CD2, CD4, CD5, CD8, B cell and granulocyte-monocyte/macrophage and antiserum against specific granules of bovine eosinophils [9].

Other interactions of CD5

  • Two clones contained RNA transcripts for CD3, TCR-alpha and beta and were positive for CD2, CD5 and CD6; one of these was a typical CD4+ class II MHC-restricted non-cytotoxic clone while the other was a CD8+ class I MHC-restricted cytotoxic clone [10].

Analytical, diagnostic and therapeutic context of CD5

  • Reactivity of the workshop CD5 panel antibodies on western blot of cell lysate [11].
  • Monoclonal antibody specific for bovine CD 5 antigen which enhances mitogen-induced blastogenesis and IL-2 production [12].


  1. B cells from bovine leukemia virus- (BLV) infected sheep with hematological disorders express the CD5 T cell marker. Letesson, J.J., Mager, A., Mammerickx, M., Burny, A., Depelchin, A. Leukemia (1990) [Pubmed]
  2. Modulation of WC1, a lineage-specific cell surface molecule of gamma/delta T cells augments cellular proliferation. Hanby-Flarida, M.D., Trask, O.J., Yang, T.J., Baldwin, C.L. Immunology (1996) [Pubmed]
  3. Monoclonal antibody BLT-1, specific for the bovine homologue of CD5, reacts with the majority of mature T cells, a subpopulation of B cells and stimulates T cell proliferation. Yang, T.J., Baldwin, C.L., Hanby-Flarida, M., Mather, J.F., Rabinovsky, E.D. Dev. Comp. Immunol. (1995) [Pubmed]
  4. Biochemical and functional characterization of 8-10C5 (gp120,90), a novel molecule on the surface of bovine T leucocytes. O'Reilly, K.L., Splitter, G.A. Immunology (1990) [Pubmed]
  5. Expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor on B-1a cell from persistent lymphocytosis (PL) cows and lymphoma cell induced by bovine leukemia virus. Murakami, K., Inumaru, S., Yokoyama, T., Okada, K., Sentsui, H. Vet. Immunol. Immunopathol. (1999) [Pubmed]
  6. Competitive binding with putative Bo5 (CD5) cluster of monoclonal antibodies. Howard, C.J., Sopp, P., Parsons, K.R. Vet. Immunol. Immunopathol. (1991) [Pubmed]
  7. Polymorphism of the CD4 and CD5 differentiation antigens in cattle. Morrison, W.I., Howard, C.J., Hinson, C.A. Vet. Immunol. Immunopathol. (1991) [Pubmed]
  8. Phenotype, growth regulation and cytokine transcription in Ovine Herpesvirus-2 (OHV-2)-infected bovine T-cell lines. Schock, A., Collins, R.A., Reid, H.W. Vet. Immunol. Immunopathol. (1998) [Pubmed]
  9. Immunohistochemical observations on cellular response in unilocular hydatid lesions and lymph nodes of cattle. Sakamoto, T., Cabrera, P.A. Acta Trop. (2003) [Pubmed]
  10. Cell surface phenotype of two cloned populations of bovine lymphocytes displaying non-specific cytotoxic activity. Goddeeris, B.M., Dunlap, S., Bensaid, A., MacHugh, N.D., Morrison, W.I. Vet. Immunol. Immunopathol. (1991) [Pubmed]
  11. Reactivity of the workshop CD5 panel antibodies on western blot of cell lysate. Letesson, J.J., Mulumba, M., Depelchin, A. Vet. Immunol. Immunopathol. (1991) [Pubmed]
  12. Monoclonal antibody specific for bovine CD 5 antigen which enhances mitogen-induced blastogenesis and IL-2 production. Letesson, J.J., Mager, A., Didembourg, C., Depelchin, A. Vet. Immunol. Immunopathol. (1990) [Pubmed]
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