Disease relevance of CD5

• B cells from bovine leukemia virus- (BLV) infected sheep with hematological disorders express the CD5 T cell marker [1].

High impact information on CD5

• Though peripheral blood B cells from healthy sheep were known to be devoid of the CD5 T cell marker, it appears from our study that most B cells from bovine leukemia virus- (BLV) infected sheep with hematological disorders express both the CD5 marker and surface IgM [1].
• In contrast, anti-CD5 mAb did not increase proliferation in the AMLR even though both CD5 and WC1 are members of the scavenger receptor cysteine-rich family of proteins and are expressed by bovine peripheral blood gamma/delta T cells [2].
• The results indicate that BLT-1 recognizes an epitope of the bovine homologue of CD5 and that perturbation of the epitope by MAb binding results in signal transduction to bovine lymphocytes [3].
• Biochemical studies included the CD2 and CD5 molecules and further demonstrated their similarity to equivalent molecules in other species, confirming the phylogenetic importance of these molecules in immune responses [4].
• Cells expressing GM-CSF receptor were Ig positive and both CD5 and CD11 positive (B-1a cell) [5].

Biological context of CD5

• Competitive binding with putative Bo5 (CD5) cluster of monoclonal antibodies [6].
• One of the CD5 allotypes was not detected in Bos taurus animals while the gene frequency of the second allotype was only about 10% in the B. indicus animals tested [7].

Anatomical context of CD5

• In competitive assays for lymphocyte surface binding, BLT-1 and MAb CC-29 (which had been shown previously to react with bovine CD5) blocked one another, indicating that the epitopes recognized were identical or extensively overlapping [3].
• All cell lines expressed CD2, CD5 and CD25 [8].
• Frozen sections of the tissues were immunohistochemically stained using monoclonal antibodies against surface markers CD2, CD4, CD5, CD8, B cell and granulocyte-monocyte/macrophage and antiserum against specific granules of bovine eosinophils [9].

Other interactions of CD5

• Two clones contained RNA transcripts for CD3, TCR-alpha and beta and were positive for CD2, CD5 and CD6; one of these was a typical CD4+ class II MHC-restricted non-cytotoxic clone while the other was a CD8+ class I MHC-restricted cytotoxic clone [10].

Analytical, diagnostic and therapeutic context of CD5

• Reactivity of the workshop CD5 panel antibodies on western blot of cell lysate [11].
• Monoclonal antibody specific for bovine CD 5 antigen which enhances mitogen-induced blastogenesis and IL-2 production [12].

References