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Gene Review

CD5  -  CD5 molecule

Gallus gallus

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High impact information on CD5

  • Alphabeta T cells express a homogeneously high level of CD5, whereas low or intermediate CD5 expression on gammadelta T cells depends on their tissue location [1].
  • The chicken CD5 is a 64-kDa phosphorylated glycoprotein with a protein core of 57 kDa as determined by immunoprecipitation and SDS-PAGE analysis [1].
  • In contrast to human and mouse, CD5 is found at low levels on all chicken B cells [1].
  • The high conservation of structural features, as well as signaling motifs, implies a conserved role for CD5 both in lymphocyte development and function [1].
  • The chicken CD5 cDNA was isolated by COS cell expression cloning utilizing a novel mAb 2-191 [1].

Biological context of CD5

  • The cDNA contains a 1422-nucleotide open reading frame encoding a mature protein with 32% and 30% identity to mouse and human CD5 polypeptides, respectively [1].
  • There are 10 exons and the introns are spliced out similarly to those in the human CD5 gene [2].
  • These results indicate that (a) mAb CTLA5 and 8 identify antigens on mature T lymphocytes that are similar in tissue distribution, molecular mass and function to the mammalian CD5 antigen; (b) mAb CTLA3, 4 and 9 detect the avian homologue of CD8 antigen; and (c) mAb CTLA1 and 6 identify the avian homologue of CD4 antigen [3].
  • After polyclonal activation, the frequency of CD28+ gammadelta T cells was increased and the activation also up-regulated CD5, CD25 and major histocompatibility complex (MHC) class II molecules [4].


  1. The structure of avian CD5 implies a conserved function. Koskinen, R., Göbel, T.W., Tregaskes, C.A., Young, J.R., Vainio, O. J. Immunol. (1998) [Pubmed]
  2. Structure and chromosomal localization of chicken CD5. Koskinen, R., Salomonsen, J., Goodchild, M., Bumstead, N., Boyd, Y., Vainio, O. Scand. J. Immunol. (2001) [Pubmed]
  3. Functional and biochemical characterizations of avian T lymphocyte antigens identified by monoclonal antibodies. Lillehoj, H.S., Lillehoj, E.P., Weinstock, D., Schat, K.A. Eur. J. Immunol. (1988) [Pubmed]
  4. Costimulatory function of CD28 in avian gammadelta T cells is evolutionarily conserved. Koskela, K., Arstila, T.P., Lassila, O. Scand. J. Immunol. (1998) [Pubmed]
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