The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Cd4  -  Cd4 molecule

Rattus norvegicus

Synonyms: T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, W3/25, W3/25 antigen, p55
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cd4


High impact information on Cd4


Associations of Cd4 with chemical compounds

  • A significant amplitude (dB) decrease was observed in all the frequency bands of the Cd4 group compared with the C4 group [10].

Regulatory relationships of Cd4

  • Fostering also down-regulated CD5 antigen expression in E compared with C offspring and up-regulated CD4 antigen expression in C offspring compared with their nonfostered counterparts [11].

Other interactions of Cd4

  • However, after fostering, E females had higher CD45RA and CD5 antigen expression compared with PF and C females, whereas E males had increased CD4 antigen expression and C males had decreased CD5 antigen expression compared with their nonfostered counterparts [11].

Analytical, diagnostic and therapeutic context of Cd4

  • The CD and magnetic circular dichroism spectra of the Cd4 cluster unit are particularly well-resolved and are remarkably similar to data of the complete Cd,Zn-MT [12].
  • Spectrophotometric titrations of rabbit liver Cd7-MT 2, apoMT, and Cd4-alpha-domain with Cu(I) revealed endpoints of 3-4, 4 and 8, and 4 and 6-7 added Cu(I)/mol of MT for the three species respectively [9].
  • More than half of the mononuclear cells in kidneys of BN rats with TIN bore various T-cell antigens (monoclonal antibodies W3-13, W3-25, and OX-8), and most of the infiltrating cells were positive for Ia (monoclonal antibody OX-6) by indirect immunofluorescence [13].


  1. Crystal structure of domains 3 and 4 of rat CD4: relation to the NH2-terminal domains. Brady, R.L., Dodson, E.J., Dodson, G.G., Lange, G., Davis, S.J., Williams, A.F., Barclay, A.N. Science (1993) [Pubmed]
  2. Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system. Sedgwick, J., Brostoff, S., Mason, D. J. Exp. Med. (1987) [Pubmed]
  3. Construction of a binding site for human immunodeficiency virus type 1 gp120 in rat CD4. Schockmel, G.A., Somoza, C., Davis, S.J., Williams, A.F., Healey, D. J. Exp. Med. (1992) [Pubmed]
  4. The mechanism of inhibition of experimental allergic encephalomyelitis in the rat by monoclonal antibody against CD4. Sedgwick, J.D., Mason, D.W. J. Neuroimmunol. (1986) [Pubmed]
  5. Modulation of CD4 antigen on macrophages and microglia in rat brain. Perry, V.H., Gordon, S. J. Exp. Med. (1987) [Pubmed]
  6. In vivo tissue distribution of CD4 lymphocytes in mice determined by radioimmunoscintigraphy with an 111In-labeled anti-CD4 monoclonal antibody. Rubin, R.H., Baltimore, D., Chen, B.K., Wilkinson, R.A., Fischman, A.J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  7. Order of metal binding in metallothionein. Nielson, K.B., Winge, D.R. J. Biol. Chem. (1983) [Pubmed]
  8. 1,25 Dihydroxyvitamin D3 exerts regional effects in the central nervous system during experimental allergic encephalomyelitis. Nataf, S., Garcion, E., Darcy, F., Chabannes, D., Muller, J.Y., Brachet, P. J. Neuropathol. Exp. Neurol. (1996) [Pubmed]
  9. Stoichiometry and cluster specificity of copper binding to metallothionein: homogeneous metal clusters. Chen, P., Munoz, A., Nettesheim, D., Shaw, C.F., Petering, D.H. Biochem. J. (1996) [Pubmed]
  10. Effect of cadmium-induced lipid peroxidation on EEG spectral components. Ağar, A., Yargiçoğlu, P., Sentürk, U.K., Izgüt-Uysal, V.N. Journal of basic and clinical physiology and pharmacology. (1999) [Pubmed]
  11. Effect of surrogate fostering on splenic lymphocytes in fetal ethanol exposed rats. Giberson, P.K., Weinberg, J. Alcohol. Clin. Exp. Res. (1997) [Pubmed]
  12. Spectroscopic properties of the alpha fragment of metallothionein. Zelazowski, A.J., Szymanska, J.A., Law, A.Y., Stillman, M.J. J. Biol. Chem. (1984) [Pubmed]
  13. Tubulointerstitial nephritis induced in the brown Norway rat with chaotropically solubilized bovine tubular basement membrane: the model and the humoral and cellular responses. Ulich, T.R., Bannister, K.M., Wilson, C.B. Clin. Immunol. Immunopathol. (1985) [Pubmed]
WikiGenes - Universities