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Gene Review:

C1QTNF9B-AS1 - C1QTNF9B antisense RNA 1

Homo sapiens

Synonyms: C1QTNF9B antisense gene protein 1, PCOTH, Prostate collagen triple helix protein

Anazawa, Y. et al.

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Disease relevance of PCOTH

Immunohistochemical analysis using polyclonal anti-PCOTH antibody confirmed elevated expression of PCOTH, a 100-amino-acid protein containing collagen triple-helix repeats, in prostate cancer cells and PINs [1].

High impact information on PCOTH

We found that the phosphorylation level of oncoprotein TAF-Ibeta/SET was significantly elevated in LNCaP cells transfected with PCOTH than control LNCaP cells, and these findings were confirmed by Western blotting and in-gel kinase assay [1].
To investigate the biological mechanisms of this growth-promoting effect, we applied two-dimensional differential gel electrophoresis (2D-DIGE) to analyze the phospho-protein fractions in LNCaP cells transfected with PCOTH [1].

Analytical, diagnostic and therapeutic context of PCOTH

Through genome-wide cDNA microarray analysis coupled with microdissection of prostate cancer cells, we identified a novel gene, prostate collagen triple helix (PCOTH), showing overexpression in prostate cancer cells and its precursor cells, prostatic intraepithelial neoplasia (PIN) [1].

References

PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET. Anazawa, Y., Nakagawa, H., Furihara, M., Ashida, S., Tamura, K., Yoshioka, H., Shuin, T., Fujioka, T., Katagiri, T., Nakamura, Y. Cancer Res. (2005) [Pubmed]

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LOC100424139	Macaca mulatta
C1QTNF9B-AS1	Pan troglodytes

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