Gene Review:
PHOSPHO1 - phosphatase, orphan 1
Homo sapiens
Synonyms:
Phosphoethanolamine/phosphocholine phosphatase
Stewart,
Schmid,
Blindauer,
Paisey,
Farquharson,
Arai,
Atomi,
Kreisberg,
Malik,
Prihoda,
Bedolla,
Troyer,
Kreisberg,
Ghosh,
de la Monte,
Chen,
Rivera,
Wands,
Houston,
Paton,
Burt,
Farquharson,
Sayós,
Martínez-Barriocanal,
Kitzig,
Bellón,
López-Botet,
Wolff,
Pfleger,
Wehner,
Reinhardt,
Richt,
Fiedler,
Serve,
Döhner,
Schwittay,
Ottmann,
O'Farrell,
Bello,
Allred,
Manning,
Cherrington,
Louie,
Hong,
Brega,
Massimini,
Scigalla,
Berdel,
Hossfeld,
Riemenschneider,
Wagenpfeil,
Vanderstichele,
Otto,
Wiltfang,
Kretzschmar,
Vanmechelen,
Förstl,
Kurz,
- Single cell profiling of potentiated phospho-protein networks in cancer cells. Irish, J.M., Hovland, R., Krutzik, P.O., Perez, O.D., Bruserud, Ø., Gjertsen, B.T., Nolan, G.P. Cell (2004)
- Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. Du, X.L., Edelstein, D., Dimmeler, S., Ju, Q., Sui, C., Brownlee, M. J. Clin. Invest. (2001)
- Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing. Isomoto, H., Mott, J.L., Kobayashi, S., Werneburg, N.W., Bronk, S.F., Haan, S., Gores, G.J. Gastroenterology (2007)
- Effects of hypoxia on radiation-responsive stress-activated protein kinase, p53, and caspase 3 signals in TK6 human lymphoblastoid cells. Samuni, A.M., Kasid, U., Chuang, E.Y., Suy, S., Degraff, W., Krishna, M.C., Russo, A., Mitchell, J.B. Cancer Res. (2005)
- Phosphorylation of Akt (Ser473) is an excellent predictor of poor clinical outcome in prostate cancer. Kreisberg, J.I., Malik, S.N., Prihoda, T.J., Bedolla, R.G., Troyer, D.A., Kreisberg, S., Ghosh, P.M. Cancer Res. (2004)
- Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases. Zhu, J.H., Guo, F., Shelburne, J., Watkins, S., Chu, C.T. Brain Pathol. (2003)
- Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias. Riemenschneider, M., Wagenpfeil, S., Vanderstichele, H., Otto, M., Wiltfang, J., Kretzschmar, H., Vanmechelen, E., Förstl, H., Kurz, A. Mol. Psychiatry (2003)
- Neuronal thread protein regulation and interaction with microtubule-associated proteins in SH-Sy5y neuronal cells. de la Monte, S.M., Chen, G.J., Rivera, E., Wands, J.R. Cell. Mol. Life Sci. (2003)
- Levels of total tau and tau protein phosphorylated at threonine 181 in patients with incipient and manifest Alzheimer's disease. Schönknecht, P., Pantel, J., Hunt, A., Volkmann, M., Buerger, K., Hampel, H., Schröder, J. Neurosci. Lett. (2003)
- Role of amygdala MAPK activation on immobility behavior of forced swim rats. Huang, T.Y., Lin, C.H. Behav. Brain Res. (2006)
- PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Shin, I., Yakes, F.M., Rojo, F., Shin, N.Y., Bakin, A.V., Baselga, J., Arteaga, C.L. Nat. Med. (2002)
- The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Dai, J., Sultan, S., Taylor, S.S., Higgins, J.M. Genes Dev. (2005)
- Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Delon, J., Kaibuchi, K., Germain, R.N. Immunity (2001)
- Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis. Le, X.F., Hittelman, W.N., Liu, J., McWatters, A., Li, C., Mills, G.B., Bast, R.C. Oncogene (2003)
- Dual and opposing roles of ERK in regulating G(1) and S-G(2)/M delays in A549 cells caused by hyperoxia. Ko, J.C., Wang, Y.T., Yang, J.L. Exp. Cell Res. (2004)
- Isoelectrofocusing of erythrocyte galactose 1 phospho uridyl transferase in a family with both galactosemia and Duarte variants. Schapira, F., Gregori, C., Banroques, J., Vidailhet, M., Despoisses, S., Vigneron, C. Hum. Genet. (1979)
- A short leucine-rich sequence in the Borna disease virus p10 protein mediates association with the viral phospho- and nucleoproteins. Wolff, T., Pfleger, R., Wehner, T., Reinhardt, J., Richt, J.A. J. Gen. Virol. (2000)
- Evidence that breast cancer associated microcalcifications are mineralized malignant cells. Castronovo, V., Bellahcene, A. Int. J. Oncol. (1998)
- Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily. Stewart, A.J., Schmid, R., Blindauer, C.A., Paisey, S.J., Farquharson, C. Protein Eng. (2003)
- Chromosomal localization of the chicken and mammalian orthologues of the orphan phosphatase PHOSPHO1 gene. Houston, B., Paton, I.R., Burt, D.W., Farquharson, C. Anim. Genet. (2002)
- Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2. Roberts, S.J., Stewart, A.J., Schmid, R., Blindauer, C.A., Bond, S.R., Sadler, P.J., Farquharson, C. Biochim. Biophys. Acta (2005)
- The presence of PHOSPHO1 in matrix vesicles and its developmental expression prior to skeletal mineralization. Stewart, A.J., Roberts, S.J., Seawright, E., Davey, M.G., Fleming, R.H., Farquharson, C. Bone (2006)
- Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice. Lang, B., Song, B., Davidson, W., MacKenzie, A., Smith, N., McCaig, C.D., Harmar, A.J., Shen, S. J. Clin. Invest. (2006)
- GAP43 stimulates inositol trisphosphate-mediated calcium release in response to hypotonicity. Caprini, M., Gomis, A., Cabedo, H., Planells-Cases, R., Belmonte, C., Viana, F., Ferrer-Montiel, A. EMBO J. (2003)
- Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities. Roberts, S.J., Stewart, A.J., Sadler, P.J., Farquharson, C. Biochem. J. (2004)
- Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes. Thuille, N., Heit, I., Fresser, F., Krumböck, N., Bauer, B., Leuthaeusser, S., Dammeier, S., Graham, C., Copeland, T.D., Shaw, S., Baier, G. EMBO J. (2005)
- Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding. Scott, M.T., Morrice, N., Ball, K.L. J. Biol. Chem. (2000)
- Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase. Hara, T., Abe, M., Inoue, H., Yu, L.R., Veenstra, T.D., Kang, Y.H., Lee, K.S., Miki, T. Oncogene (2006)
- Recruitment of C-terminal Src kinase by the leukocyte inhibitory receptor CD85j. Sayós, J., Martínez-Barriocanal, A., Kitzig, F., Bellón, T., López-Botet, M. Biochem. Biophys. Res. Commun. (2004)
- Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Li, J., Williams, B.L., Haire, L.F., Goldberg, M., Wilker, E., Durocher, D., Yaffe, M.B., Jackson, S.P., Smerdon, S.J. Mol. Cell (2002)
- Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription. Blaydes, J.P., Luciani, M.G., Pospisilova, S., Ball, H.M., Vojtesek, B., Hupp, T.R. J. Biol. Chem. (2001)
- Phorbol esters potentiate tyrosine phosphorylation of epidermal growth factor receptors in A431 membranes by a calcium-independent mechanism. Moon, S.O., Palfrey, H.C., King, A.C. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Glyoxal and methylglyoxal induce lyoxal and methyglyoxal induce aggregation and inactivation of ERK in human endothelial cells. Akhand, A.A., Hossain, K., Kato, M., Miyata, T., Du, J., Suzuki, H., Kurokawa, K., Nakashima, I. Free Radic. Biol. Med. (2001)
- Suppression of cofilin phosphorylation in insulin-stimulated ruffling membrane formation in KB cells. Arai, H., Atomi, Y. Cell Struct. Funct. (2003)
- Role of membrane microdomains in PTH-mediated down-regulation of NaPi-IIa in opossum kidney cells. Nashiki, K., Taketani, Y., Takeichi, T., Sawada, N., Yamamoto, H., Ichikawa, M., Arai, H., Miyamoto, K., Takeda, E. Kidney Int. (2005)
- Acute allergen-induced airway remodeling in atopic asthma. Phipps, S., Benyahia, F., Ou, T.T., Barkans, J., Robinson, D.S., Kay, A.B. Am. J. Respir. Cell Mol. Biol. (2004)
- DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci. Robison, J.G., Lu, L., Dixon, K., Bissler, J.J. J. Biol. Chem. (2005)
- Levels of phospho-Smad2/3 are sensors of the interplay between effects of TGF-beta and retinoic acid on monocytic and granulocytic differentiation of HL-60 cells. Cao, Z., Flanders, K.C., Bertolette, D., Lyakh, L.A., Wurthner, J.U., Parks, W.T., Letterio, J.J., Ruscetti, F.W., Roberts, A.B. Blood (2003)
- Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease. Johansson, A., Katzov, H., Zetterberg, H., Feuk, L., Johansson, B., Bogdanovic, N., Andreasen, N., Lenhard, B., Brookes, A.J., Pedersen, N.L., Blennow, K., Prince, J.A. Hum. Genet. (2004)
- Constitutive thrombospondin-1 overexpression contributes to autocrine transforming growth factor-beta signaling in cultured scleroderma fibroblasts. Mimura, Y., Ihn, H., Jinnin, M., Asano, Y., Yamane, K., Tamaki, K. Am. J. Pathol. (2005)
- Stabilization and functional impairment of the tumor suppressor p53 by the human papillomavirus type 16 E7 oncoprotein. Eichten, A., Westfall, M., Pietenpol, J.A., Münger, K. Virology (2002)
- Mitotic regulation of the human anaphase-promoting complex by phosphorylation. Kraft, C., Herzog, F., Gieffers, C., Mechtler, K., Hagting, A., Pines, J., Peters, J.M. EMBO J. (2003)
- Specific down-regulation of interleukin-12 signaling through induction of phospho-STAT4 protein degradation. Wang, K.S., Zorn, E., Ritz, J. Blood (2001)
- Glycogen synthase kinase 3 phosphorylates RBL2/p130 during quiescence. Litovchick, L., Chestukhin, A., DeCaprio, J.A. Mol. Cell. Biol. (2004)
- The Src kinase Lyn is required for CCR5 signaling in response to MIP-1beta and R5 HIV-1 gp120 in human macrophages. Tomkowicz, B., Lee, C., Ravyn, V., Cheung, R., Ptasznik, A., Collman, R.G. Blood (2006)
- A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Fiedler, W., Serve, H., Döhner, H., Schwittay, M., Ottmann, O.G., O'Farrell, A.M., Bello, C.L., Allred, R., Manning, W.C., Cherrington, J.M., Louie, S.G., Hong, W., Brega, N.M., Massimini, G., Scigalla, P., Berdel, W.E., Hossfeld, D.K. Blood (2005)
- Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells. Rössig, L., Jadidi, A.S., Urbich, C., Badorff, C., Zeiher, A.M., Dimmeler, S. Mol. Cell. Biol. (2001)
- Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia. Ljungberg, M.C., Bhattacharjee, M.B., Lu, Y., Armstrong, D.L., Yoshor, D., Swann, J.W., Sheldon, M., D'Arcangelo, G. Ann. Neurol. (2006)